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NCT04365257 · ClinicalTrials.gov registry record · Phase 2

Prazosin to Prevent COVID-19 (PREVENT-COVID Trial)

A Phase 2 study, sponsored by Johns Hopkins University.

Terminated
Registry status
Phase 2
Development phase
5
Enrollment target

NCT04365257: Clinical Trial Phase 2 study, sponsored by Johns Hopkins University.

NCT04365257 is a Phase 2 study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 5 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

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The verdict

NCT04365257, a Phase 2 study, was terminated before completion, sponsored by Johns Hopkins University.

TERMINATED
Registry status
Phase 2
Development phase
5 participants
Enrollment target

Study Summary

The purpose of this study is to assess the efficacy and safety of prazosin to prevent cytokine storm syndrome and severe complications in hospitalized patients with Coronavirus disease 2019 (COVID-19).

Primary Outcome

Number of participants in each arm who expire.

Interventions

  • OTHER Standard of care
  • DRUG Prazosin

Trial Details

FieldValue
Enrollment Target 5 participants
Start Date 2020-05-13
Est. Completion 2022-03-31
Phase Phase 2
Johns Hopkins University

1,448 total trials

Why NCT04365257 stopped before completion

NCT04365257 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (96% lower).

The record links to 0 conditions, and to 2 interventions - of which Standard of care is the first listed.

NCT04365257 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT04365257 about?

NCT04365257 is a clinical study titled "Prazosin to Prevent COVID-19 (PREVENT-COVID Trial)". The purpose of this study is to assess the efficacy and safety of prazosin to prevent cytokine storm syndrome and severe complications in hospitalized patients with Coronavirus disease 2019 (COVID-19).

What is the current status of trial NCT04365257?

This trial is currently terminated. It is a Phase 2 study. The enrollment target is 5 participants. The study started on 2020-05-13. Estimated completion is 2022-03-31.

What interventions are being tested in trial NCT04365257?

The interventions under investigation include: Standard of care (OTHER), Prazosin (DRUG).

Who is sponsoring clinical trial NCT04365257?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

How this trial's enrollment target compares

Where NCT04365257's enrollment target sits among peer trials

5 2000th of 2000 the lowest of 2,000 other Phase 2 trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT04365257, the US trial registry maintained by the National Library of Medicine. NCT04365257 (small enrollment · none site footprint · terminated) retrieved and formatted by PlainTrial, see methodology.