Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT04359108 · ClinicalTrials.gov registry record · NA

Environmental Localization Mapping and Guidance for Visual Prosthesis Users

A NA study, sponsored by Johns Hopkins University.

Completed
Registry status
NA
Development phase
26
Enrollment target

NCT04359108: Completed NA study, sponsored by Johns Hopkins University.

NCT04359108 is a NA study that has completed, run by Johns Hopkins University. The registered enrollment target is 26 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist → Add completion date to calendar (.ics) →

The verdict

NCT04359108, a NA study, has completed, sponsored by Johns Hopkins University.

COMPLETED
Registry status
NA
Development phase
26 participants
Enrollment target

Study Summary

This study is driven by the hypothesis that independent navigation by blind users of visual prosthetic devices can be greatly aided by use of an autonomous navigational aid that provides information about the environment and guidance for navigation through multimodal sensory cues. For this study, the investigators developed a navigation system that uses on-board sensing to map the user's environment and compute navigable paths to desired destinations in real-time. Information regarding obstacles and directional guidance is communicated to the user via a combination of sensory modalities including limited vision (through the user's visual prosthesis), haptic, and audio cues. This study evaluates how effectively this navigational aid improves prosthetic vision users' ability to perform navigational tasks. The participants for this study include both retinal prosthesis users of the Argus II Retinal Prosthesis System (Argus II) and normally sighted individuals who use a virtual reality headset to simulate the limited vision of the Argus II system.

Primary Outcome

Participants will be asked to complete the navigation tasks of crossing an obstacle field approximately 6 meters in length and navigating to a target destination located about 20 - 30 meters away. The normalized duration of time to complete each navigation task will be measured in seconds. To account for variability in the path distances of different trials, the measured time will be normalized by a reference (nominal) path distance in meters associated with the configuration of each trial. The

Interventions

  • DEVICE Navigation system mode: Argus Vision
  • DEVICE Navigation system mode: Depth Vision
  • DEVICE Navigation system mode: Depth Vision with Haptic / Audio
  • DEVICE Navigation system mode: Haptic / Audio
  • DEVICE Navigation system mode: High Field-of-View Depth Vision

Trial Details

FieldValue
Enrollment Target 26 participants
Start Date 2021-03-16
Est. Completion 2024-09-30
Phase NA
Johns Hopkins University

1,448 total trials

What the finished NCT04359108 record still lists

NCT04359108 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).

The record links to 0 conditions, and to 5 interventions - of which Navigation system mode: Argus Vision is the first listed.

NCT04359108 does not publish any study locations in the registry export this page uses.

Frequently Asked Questions

What is clinical trial NCT04359108 about?

NCT04359108 is a clinical study titled "Environmental Localization Mapping and Guidance for Visual Prosthesis Users". This study is driven by the hypothesis that independent navigation by blind users of visual prosthetic devices can be greatly aided by use of an autonomous navigational aid that provides information about the environment and guidance for navigation through multimodal sensory cues. For this study, th...

What is the current status of trial NCT04359108?

This trial is currently completed. It is a NA study. The enrollment target is 26 participants. The study started on 2021-03-16. Estimated completion is 2024-09-30.

What interventions are being tested in trial NCT04359108?

The interventions under investigation include: Navigation system mode: Argus Vision (DEVICE), Navigation system mode: Depth Vision (DEVICE), Navigation system mode: Depth Vision with Haptic / Audio (DEVICE), Navigation system mode: Haptic / Audio (DEVICE), Navigation system mode: High Field-of-View Depth Vision (DEVICE).

Who is sponsoring clinical trial NCT04359108?

This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.

Learn More About Clinical Trials

How this trial's enrollment target compares

Where NCT04359108's enrollment target sits among peer trials

26 1710th of 2000 higher than 289 of 2,000 other NA trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT02646475 · 26 participants · Phase 1

    Metabolic Effects of Angiotensin-(1-7)

  • NCT03603223 · 26 participants · Phase 2

    Pembrolizumab in Treating Participants With Leukoplakia

  • NCT04063592 · 26 participants · NA

    AMI Construction in Lower Extremity Residual Limbs

  • NCT04906460 · 26 participants · Phase 1

    Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)

Similar registry start date

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

  • NCT07125183 · started 2026-12 · Phase 2

    Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma

  • NCT07292298 · started 2026-11 · Phase 2

    Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

  • NCT04263285 · started 2026-10 · NA

    Treatment of Depression Post-SCI

Source: ClinicalTrials.gov NCT04359108, the US trial registry maintained by the National Library of Medicine. NCT04359108 (small enrollment · none site footprint · completed) retrieved and formatted by PlainTrial, see methodology.