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NCT04330664 · ClinicalTrials.gov registry record · Phase 1
Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)
A Phase 1 study, sponsored by Mirati Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 86
- Enrollment target
NCT04330664: Completed Phase 1 study, sponsored by Mirati Therapeutics.
NCT04330664 is a Phase 1 study that has completed, run by Mirati Therapeutics. The registered enrollment target is 86 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (43% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04330664, a Phase 1 study, has completed, sponsored by Mirati Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 86 participants
- Enrollment target
Study Summary
This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 in combination with TNO155 in patients with advanced solid tumors that have a KRAS G12C mutation.
Primary Outcome
Number of participants with treatment related adverse events
Interventions
- DRUG MRTX849
- DRUG TNO155
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 86 participants |
| Start Date | 2020-04-07 |
| Est. Completion | 2025-02-24 |
| Phase | Phase 1 |
What the finished NCT04330664 record still lists
NCT04330664 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 86 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (43% higher).
The record links to 0 conditions, and to 2 interventions - of which MRTX849 is the first listed.
NCT04330664 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04330664 about?
NCT04330664 is a clinical study titled "Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)". This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 in combination with TNO155 in patients with advanced solid tumors that have a KRAS G12C mutation.
What is the current status of trial NCT04330664?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 86 participants. The study started on 2020-04-07. Estimated completion is 2025-02-24.
What interventions are being tested in trial NCT04330664?
The interventions under investigation include: MRTX849 (DRUG), TNO155 (DRUG).
Who is sponsoring clinical trial NCT04330664?
This trial is sponsored by Mirati Therapeutics, which has 49 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04330664's enrollment target sits among peer trials
86 652nd of 2000 higher than 1,345 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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