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NCT04327999 · ClinicalTrials.gov registry record · Phase 2
Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System
A Phase 2 study, sponsored by Vanderbilt-Ingram Cancer Center.
- Terminated
- Registry status
- Phase 2
- Development phase
- 9
- Enrollment target
NCT04327999: Clinical Trial Phase 2 study, sponsored by Vanderbilt-Ingram Cancer Center.
NCT04327999 is a Phase 2 study that was terminated before completion, run by Vanderbilt-Ingram Cancer Center. The registered enrollment target is 9 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04327999, a Phase 2 study, was terminated before completion, sponsored by Vanderbilt-Ingram Cancer Center.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 9 participants
- Enrollment target
Study Summary
The purpose of this study is to explore whether administration of preservative free artificial tears will decrease the level of detectable radioiodine in the tears and nasolacrimal duct system of patients undergoing radioiodine therapy for thyroid carcinoma and thus decrease the risk of developing radioactive iodine associated nasolacrimal duct obstruction.
Primary Outcome
The radioactive iodine activity level in the tears will be measured, as collected via contact lenses. Each patient will have a control eye and an experimental eye that received artificial tears. The control eye has no intervention. The radioactive iodine activity level will be measured over four days, with Day 1 occurring on the Day of systemic radioactive iodine therapy. On each of the four days, the level of radioactive iodine will be compared between the control and experimental eyes to see i
Interventions
- DRUG Artificial Tears
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2020-10-05 |
| Est. Completion | 2023-09-25 |
| Phase | Phase 2 |
Why NCT04327999 stopped before completion
NCT04327999 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 1 intervention - of which Artificial Tears is the first listed.
NCT04327999 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04327999 about?
NCT04327999 is a clinical study titled "Effect of Artificial Tears on Radioiodine Levels in the Nasolacrimal Duct System". The purpose of this study is to explore whether administration of preservative free artificial tears will decrease the level of detectable radioiodine in the tears and nasolacrimal duct system of patients undergoing radioiodine therapy for thyroid carcinoma and thus decrease the risk of developing r...
What is the current status of trial NCT04327999?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 9 participants. The study started on 2020-10-05. Estimated completion is 2023-09-25.
What interventions are being tested in trial NCT04327999?
The interventions under investigation include: Artificial Tears (DRUG).
Who is sponsoring clinical trial NCT04327999?
This trial is sponsored by Vanderbilt-Ingram Cancer Center, which has 189 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04327999's enrollment target sits among peer trials
9 1989th of 2000 higher than 11 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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