Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04325321 · ClinicalTrials.gov registry record · NA
The Broken Heart Study II (BHS-II)
A NA study of Takotsubo Cardiomyopathy, sponsored by The Miriam Hospital.
- Active
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT04325321: Active NA study of Takotsubo Cardiomyopathy, sponsored by The Miriam Hospital.
NCT04325321 is a NA study of Takotsubo Cardiomyopathy that is active but no longer recruiting, run by The Miriam Hospital. The registered enrollment target is 66 participants, below the 508-participant average among 3 other Takotsubo Cardiomyopathy trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04325321, a NA study of Takotsubo Cardiomyopathy, is active but no longer recruiting, sponsored by The Miriam Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
The goals of this study are as follows: 1. To rigorously establish and characterize heterogeneity in the pathophysiology of Takotsubo Syndrome (TS). 2. To rigorously test the contribution of TS triggering events and mental stress responsiveness to 1-year prognosis after TS event.
Primary Outcome
Blood samples for plasma epinephrine are collected 10-min into Baseline, 10-min into Emotion Recall, and 18 minutes into Recovery Phase. Change will be calculated by subtracting Baseline epinephrine levels from Emotion Recall levels.
Conditions Studied
Interventions
- OTHER Stress reactivity test
Study Locations (1)
Rhode Island
- The Miriam Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2020-09-02 |
| Est. Completion | 2026-02 |
| Phase | NA |
What the registry record for NCT04325321 still lists
NCT04325321 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, below the 508-participant average among 3 other Takotsubo Cardiomyopathy trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Takotsubo Cardiomyopathy appearing as the primary indexed condition, and to 1 intervention - of which Stress reactivity test is the first listed.
NCT04325321 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT04325321 about?
NCT04325321 is a clinical study titled "The Broken Heart Study II (BHS-II)". The goals of this study are as follows: 1. To rigorously establish and characterize heterogeneity in the pathophysiology of Takotsubo Syndrome (TS). 2. To rigorously test the contribution of TS triggering events and mental stress responsiveness to 1-year prognosis after TS event.
What is the current status of trial NCT04325321?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2020-09-02. Estimated completion is 2026-02.
What conditions does trial NCT04325321 study?
This clinical trial studies the following conditions: Takotsubo Cardiomyopathy.
What interventions are being tested in trial NCT04325321?
The interventions under investigation include: Stress reactivity test (OTHER).
Who is sponsoring clinical trial NCT04325321?
This trial is sponsored by The Miriam Hospital, which has 136 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04325321 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Takotsubo Cardiomyopathy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02584244 · 66 participants · Phase 1
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
- NCT03067051 · 66 participants · Phase 1
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
- NCT03754725 · 66 participants · Phase 1
Ferritin and Iron Burden in SAH sIRB
- NCT03875378 · 66 participants · Phase 2
Transdermal Estrogen in Women With Anorexia Nervosa
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI