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NCT04322968 · ClinicalTrials.gov registry record · Phase 3
Ketamine Infusion for Comorbid PTSD and Chronic Pain
A Phase 3 study, sponsored by VA Ann Arbor Healthcare System.
- Completed
- Registry status
- Phase 3
- Development phase
- 41
- Enrollment target
NCT04322968: Completed Phase 3 study, sponsored by VA Ann Arbor Healthcare System.
NCT04322968 is a Phase 3 study that has completed, run by VA Ann Arbor Healthcare System. The registered enrollment target is 41 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04322968, a Phase 3 study, has completed, sponsored by VA Ann Arbor Healthcare System.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 41 participants
- Enrollment target
Study Summary
The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the treatment and such an effect is not only due to its analgesic properties but also through unknown mechanism of action that maybe related to NMDA/AMPA receptor modulation.
Primary Outcome
Severity of PTSD symptoms; items are rated on a 5-point scale ranging from 0 ("not at all") to 4 ("extremely"). The IES-R yields a total score (ranging from 0 to 88); higher scores mean worse symptoms
Interventions
- DRUG A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2018-01-09 |
| Est. Completion | 2019-06-04 |
| Phase | Phase 3 |
What the finished NCT04322968 record still lists
NCT04322968 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms. is the first listed.
NCT04322968 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04322968 about?
NCT04322968 is a clinical study titled "Ketamine Infusion for Comorbid PTSD and Chronic Pain". The purpose of the study is to investigate the effectiveness of low dose IV ketamine infusion in the treatment of patients with PTSD and comorbid chronic pain. Hypothesis: A single ketamine infusion should be associated with significantly greater reduction in core PTSD symptom levels after the trea...
What is the current status of trial NCT04322968?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 41 participants. The study started on 2018-01-09. Estimated completion is 2019-06-04.
What interventions are being tested in trial NCT04322968?
The interventions under investigation include: A single low dose ketamine infusion as compared to the IV infusion of active placebo - ketorolac on chronic pain and PTSD symptoms. (DRUG).
Who is sponsoring clinical trial NCT04322968?
This trial is sponsored by VA Ann Arbor Healthcare System, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04322968's enrollment target sits among peer trials
41 1877th of 2000 higher than 123 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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