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NCT04322630 · ClinicalTrials.gov registry record
Mer-TK in Human Cardiac Cells
A clinical trial, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- Completed
- Registry status
- 50
- Enrollment target
NCT04322630 is a clinical trial that has completed, run by Ann & Robert H Lurie Children's Hospital of Chicago. The registered enrollment target is 50 participants.
The verdict
NCT04322630 has completed, sponsored by Ann & Robert H Lurie Children's Hospital of Chicago.
- COMPLETED
- Registry status
- 50 participants
- Enrollment target
Study Summary
The relationship between the immune system and the myocardium after myocardial ischemia is an evolving field of research. Crosstalk occurs between macrophages and cardiac myocytes to promote cardio-protection and resolution of inflammation after myocardial ischemia and reperfusion injury (MI/R injury). Myeloid-epithelial-reproductive tyrosine kinase (MerTK), a member of the TAM family of tyrosine kinase receptors (Tyro-Axl-MerTK), is a macrophage receptor that mediates efferocytosis, anti-inflammatory signaling, and resolution of inflammation. After MI/R injury, intact MerTK is necessary for the phagocytosis of dead cardiac myocytes and to promote anti-inflammatory signaling. Proteolytic cleavage of MerTK to its inactive form, soluble MER, restricts the capacity of macrophages to phagocytize dead cardiac myocytes and impairs MerTK-dependent anti-inflammatory signaling resulting in suppressive effects on cardiac remodeling and function. The Thorp lab at Northwestern University has previously measured soluble MER levels in both adult mice and humans and found that soluble MER concentrations increase after MI/R injury. In adult MI patients, soluble MER was measured post coronary artery reperfusion and was found to be increased (average 3200 pg/mL compared to 1700 pg/mL) compared to controls with stable cardiovascular disease. Based on murine data, the lab further postulated that reperfusion injury may directly interfere with MerTK-dependent cardiac repair as reactive oxygen species formed during reperfusion injury induce proteolytic cleavage of MerTK to soluble MER. Myocardial infarctions are rare events in pediatric patients. However, pediatric hearts are exposed to periods of hypoperfusion, ischemia, and inflammation during times of stress such as cardiac bypass and critical illness, and it is unknown how soluble MER levels change in response to these events. Thus, I was interested in investigating how soluble MER levels change after MI/R injury induced by cardiac
Interventions
- OTHER Change in Soluble MER Concentration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2019-05-10 |
| Est. Completion | 2020-12-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04322630
The ClinicalTrials.gov registry entry for NCT04322630 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Change in Soluble MER Concentration is the first listed.
NCT04322630 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04322630 about?
NCT04322630 is a clinical study titled "Mer-TK in Human Cardiac Cells". The relationship between the immune system and the myocardium after myocardial ischemia is an evolving field of research. Crosstalk occurs between macrophages and cardiac myocytes to promote cardio-protection and resolution of inflammation after myocardial ischemia and reperfusion injury (MI/R injur...
What is the current status of trial NCT04322630?
This trial is currently completed. The enrollment target is 50 participants. The study started on 2019-05-10. Estimated completion is 2020-12-31.
What interventions are being tested in trial NCT04322630?
The interventions under investigation include: Change in Soluble MER Concentration (OTHER).
Who is sponsoring clinical trial NCT04322630?
This trial is sponsored by Ann & Robert H Lurie Children's Hospital of Chicago, which has 159 total clinical trials registered on ClinicalTrials.gov.
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