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NCT04307667 · ClinicalTrials.gov registry record
Microglia Activation in Asthma
A clinical trial of Asthma, sponsored by University of Wisconsin, Madison.
- Recruiting
- Registry status
- 50
- Enrollment target
- 1
- Study location
NCT04307667: Recruiting study of Asthma, sponsored by University of Wisconsin, Madison.
NCT04307667 is a study of Asthma that is actively recruiting participants, run by University of Wisconsin, Madison. The registered enrollment target is 50 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04307667, a study of Asthma, is actively recruiting participants, sponsored by University of Wisconsin, Madison.
- RECRUITING
- Registry status
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trail is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 6 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test * Undergo breathing tests including two whole lung allergen challenges * Give four blood samples * Complete brain imaging scans
Primary Outcome
The investigators propose that, in subjects with asthma, provocation of airway inflammation activates microglia, indicative of a neuroinflammatory signal. The hypothesis is that microglial activation will occur following an inhaled allergen challenge, relative to pre-challenge. Activation of microglia will be measured using positron emission tomography (PET) with the radiotracer \[18F\]FEPPA, a tracer selective for translocator protein (TSPO) binding, which is elevated in activated microglia.
Conditions Studied
Interventions
- BIOLOGICAL Whole lung antigen challenge (WLAC)
- RADIATION [18F]FEPPA
Study Locations (1)
Wisconsin
- University of Wisconsin Madison - Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2019-12-17 |
| Est. Completion | 2028-08-01 |
What NCT04307667 shows while recruiting
NCT04307667 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which Whole lung antigen challenge (WLAC) is the first listed.
NCT04307667 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT04307667 about?
NCT04307667 is a clinical study titled "Microglia Activation in Asthma". The goal of this clinical trail is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of ...
What is the current status of trial NCT04307667?
This trial is currently recruiting. The enrollment target is 50 participants. The study started on 2019-12-17. Estimated completion is 2028-08-01.
What conditions does trial NCT04307667 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT04307667?
The interventions under investigation include: Whole lung antigen challenge (WLAC) (BIOLOGICAL), [18F]FEPPA (RADIATION).
Who is sponsoring clinical trial NCT04307667?
This trial is sponsored by University of Wisconsin, Madison, which has 1,039 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04307667 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04307667's enrollment target sits among peer trials
50 263rd of 374 higher than 106 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Measuring the Effect of Dupilumab Treatment on Mucociliary Clearance (MCC) in Subjects With Moderate to Severe Asthma
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