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NCT04289454 · ClinicalTrials.gov registry record · NA
Sensory Analysis and Taste Modulation of Ketone Esters
A NA study, sponsored by Monell Chemical Senses Center.
- Completed
- Registry status
- NA
- Development phase
- 19
- Enrollment target
NCT04289454: Completed NA study, sponsored by Monell Chemical Senses Center.
NCT04289454 is a NA study that has completed, run by Monell Chemical Senses Center. The registered enrollment target is 19 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04289454, a NA study, has completed, sponsored by Monell Chemical Senses Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 19 participants
- Enrollment target
Study Summary
Ketone ester (KE) drinks are sold commercially in the USA and elsewhere (the FDA has accepted a GRAS (generally regarded as safe) notification on the KEs we propose to study). KE drinks can have beneficial effects on metabolism. Unfortunately, KE drinks have a strongly unpleasant flavor which can trigger rejection. The current study will generate data to help inform KE drink formulations with improved flavor. First stage, trained subjects will rate the intensity of various sensation qualities (e.g., bitter, sour, metallic, and astringent) from KE drinks to help understand the nature of the unpleasant flavor and the particular sensory systems involved (e.g., taste vs. smell). Then, subjects will taste KE drinks with and without various flavor modifiers. Subjects will be healthy adults (aged 21-45) without known food allergies.
Primary Outcome
Rated intensity of taste qualities (e.g., sour, bitter) and mouth-feel (astringent) of model drinks, measured using the general Labeled Magnitude Scale (gLMS). In this implementation of the gLMS, scores will range from 0 (or "no sensation") up to 100 ("strongest imaginable sensation"), with higher scores indicating stronger perceived intensity for the sensation in question.
Interventions
- OTHER Flavor additive
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 19 participants |
| Start Date | 2020-08-30 |
| Est. Completion | 2021-06-04 |
| Phase | NA |
What the finished NCT04289454 record still lists
NCT04289454 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 19 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 1 intervention - of which Flavor additive is the first listed.
NCT04289454 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04289454 about?
NCT04289454 is a clinical study titled "Sensory Analysis and Taste Modulation of Ketone Esters". Ketone ester (KE) drinks are sold commercially in the USA and elsewhere (the FDA has accepted a GRAS (generally regarded as safe) notification on the KEs we propose to study). KE drinks can have beneficial effects on metabolism. Unfortunately, KE drinks have a strongly unpleasant flavor which can tr...
What is the current status of trial NCT04289454?
This trial is currently completed. It is a NA study. The enrollment target is 19 participants. The study started on 2020-08-30. Estimated completion is 2021-06-04.
What interventions are being tested in trial NCT04289454?
The interventions under investigation include: Flavor additive (OTHER).
Who is sponsoring clinical trial NCT04289454?
This trial is sponsored by Monell Chemical Senses Center, which has 16 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04289454's enrollment target sits among peer trials
19 1861st of 2000 higher than 138 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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