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NCT04281199 · ClinicalTrials.gov registry record · Phase 1
TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT
A Phase 1 study of Myelodysplastic Syndrome and Acute Leukemia, sponsored by City of Hope Medical Center.
- Active
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT04281199: Active Phase 1 study of Myelodysplastic Syndrome and Acute Leukemia, sponsored by City of Hope Medical Center.
NCT04281199 is a Phase 1 study of Myelodysplastic Syndrome and Acute Leukemia that is active but no longer recruiting, run by City of Hope Medical Center. The registered enrollment target is 20 participants, below the 207-participant average among 134 other Myelodysplastic Syndrome trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04281199, a Phase 1 study of Myelodysplastic Syndrome and Acute Leukemia, is active but no longer recruiting, sponsored by City of Hope Medical Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This trial studies how well radiation therapy techniques, volumetric modulated arc therapy (VMAT) and tomotherapy, work to reduce doses to the lung compared to standard total body irradiation methods to prevent pulmonary toxicities. Standard total body irradiation is limited in its ability to spare normal organs, with only the lung being partially spared by lung blocks and risks the development of pulmonary toxicities. Reducing the doses to the lung using VMAT or tomotherapy may improve survival and decrease long term lung side effects in patients undergoing stem cell transplant.
Primary Outcome
Will be summarized using percentage and its 95% confidence interval.
Conditions Studied
Interventions
- RADIATION Total-Body Irradiation
- RADIATION Intensity-Modulated Radiation Therapy
- PROCEDURE Hematopoietic Cell Transplantation
- RADIATION Volume Modulated Arc Therapy
- RADIATION Tomotherapy
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2020-02-28 |
| Est. Completion | 2026-07-14 |
| Phase | Phase 1 |
What the registry record for NCT04281199 still lists
NCT04281199 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 207-participant average among 134 other Myelodysplastic Syndrome trials with a reported enrollment target (90% lower).
The record links to 2 conditions, with Myelodysplastic Syndrome appearing as the primary indexed condition, and to 5 interventions - of which Total-Body Irradiation is the first listed.
NCT04281199 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04281199 about?
NCT04281199 is a clinical study titled "TBI Using IMRT (VMAT or Tomotherapy) for the Prevention of Pul Toxicities in Patients Undergoing Donor SCT". This trial studies how well radiation therapy techniques, volumetric modulated arc therapy (VMAT) and tomotherapy, work to reduce doses to the lung compared to standard total body irradiation methods to prevent pulmonary toxicities. Standard total body irradiation is limited in its ability to spare ...
What is the current status of trial NCT04281199?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2020-02-28. Estimated completion is 2026-07-14.
What conditions does trial NCT04281199 study?
This clinical trial studies the following conditions: Myelodysplastic Syndrome, Acute Leukemia.
What interventions are being tested in trial NCT04281199?
The interventions under investigation include: Total-Body Irradiation (RADIATION), Intensity-Modulated Radiation Therapy (RADIATION), Hematopoietic Cell Transplantation (PROCEDURE), Volume Modulated Arc Therapy (RADIATION), Tomotherapy (RADIATION).
Who is sponsoring clinical trial NCT04281199?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04281199 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04281199's enrollment target sits among peer trials
20 114th of 134 higher than 19 of 134 other Myelodysplastic Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Myelodysplastic Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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