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NCT04270760 · ClinicalTrials.gov registry record · Phase 2
Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study
A Phase 2 study, sponsored by Amgen.
- Completed
- Registry status
- Phase 2
- Development phase
- 281
- Enrollment target
NCT04270760: Completed Phase 2 study, sponsored by Amgen.
NCT04270760 is a Phase 2 study that has completed, run by Amgen. The registered enrollment target is 281 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (111% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04270760, a Phase 2 study, has completed, sponsored by Amgen.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 281 participants
- Enrollment target
Study Summary
Evaluate the effect of olpasiran administered subcutaneously (SC) compared with placebo, on percent change from baseline in lipoprotein(a) (Lp\[a\]).
Primary Outcome
Least squares mean is from the repeated measures linear effects model which includes treatment group, stratification factors, scheduled visit and the interaction of treatment group with scheduled visit.
Interventions
- DRUG Placebo
- DRUG Olpasiran
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 281 participants |
| Start Date | 2020-07-28 |
| Est. Completion | 2022-11-08 |
| Phase | Phase 2 |
What the finished NCT04270760 record still lists
NCT04270760 is an interventional study that assigns participants to a tested intervention. The registered 281 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (111% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04270760 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04270760 about?
NCT04270760 is a clinical study titled "Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study". Evaluate the effect of olpasiran administered subcutaneously (SC) compared with placebo, on percent change from baseline in lipoprotein(a) (Lp\[a\]).
What is the current status of trial NCT04270760?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 281 participants. The study started on 2020-07-28. Estimated completion is 2022-11-08.
What interventions are being tested in trial NCT04270760?
The interventions under investigation include: Placebo (DRUG), Olpasiran (DRUG).
Who is sponsoring clinical trial NCT04270760?
This trial is sponsored by Amgen, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04270760's enrollment target sits among peer trials
281 196th of 2000 higher than 1,805 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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