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Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment
NCT04262336 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to evaluate whether DB-020 administered via an injection in the middle ear prevents hearing loss in participants who will receive high doses of cisplatin as part of their treatment for cancer.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG DB-020
Study Locations (8)
Victoria
- Peter MacCallum Cancer Centre — Melbourne
- Oncology and Palliative Care Research — Melbourne
Florida
- University of Miami Health System — Miami
Kansas
- University of Kansas Medical Center — Kansas City
New York
- Northwell Health Cancer Center — Lake Success
West Virginia
- WVU Cancer Institute — Morgantown
Queensland
- Queensland Head and Neck Cancer Centre — Woolloongabba
Western Australia
- Fiona Stanley Hospital, Clinical Trials Unit Cancer Center — Murdoch
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2020-02-21 |
| Est. Completion | 2023-05-23 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04262336
The ClinicalTrials.gov registry entry for NCT04262336 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Decibel Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Ototoxicity appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04262336 reports 8 study locations spanning 7 distinct geographic areas — top geographies include Victoria, Florida, Kansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04262336 about?
NCT04262336 is a clinical study titled "Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment". The purpose of this study is to evaluate whether DB-020 administered via an injection in the middle ear prevents hearing loss in participants who will receive high doses of cisplatin as part of their treatment for cancer.
What is the current status of trial NCT04262336?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 22 participants. The study started on 2020-02-21. Estimated completion is 2023-05-23.
What conditions does trial NCT04262336 study?
This clinical trial studies the following conditions: Ototoxicity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04262336?
The interventions under investigation include: Placebo (DRUG), DB-020 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04262336?
This trial is sponsored by Decibel Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04262336 being conducted?
This trial has 8 study locations across Florida, Kansas, New York, West Virginia, Queensland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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