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NCT04262258 · ClinicalTrials.gov registry record · NA
Effects of a Blueberry Enriched Diet on the Skeletal Muscle Regenerative Process
A NA study, sponsored by Cornell University.
- Completed
- Registry status
- NA
- Development phase
- 22
- Enrollment target
NCT04262258 is a NA study that has completed, run by Cornell University. The registered enrollment target is 22 participants.
The verdict
NCT04262258, a NA study, has completed, sponsored by Cornell University.
- COMPLETED
- Registry status
- NA
- Development phase
- 22 participants
- Enrollment target
Study Summary
One of the greatest challenges faced by older adults is maintaining physical function and strength with aging. Deterioration of skeletal muscle with aging leads to loss of mobility, decreased quality of life, and ultimately loss of independence. Skeletal muscle deterioration with aging is multifactorial, with a key factor being impaired skeletal muscle regeneration following damage. Muscle regeneration is a multistep process that requires a viable population of skeletal muscle specific progenitor cells (MPCs). MPCs reside in the skeletal muscle in a dormant state until activated by stress or injury cues. Upon activation, MPCs divide, commit to the muscle cell lineage, and fuse to form new multinucleated cells or repair damaged muscle cells. In older adults this regenerative process is impaired, which amplifies skeletal muscle deterioration. The investigators demonstrated that the ability of MPCs to divide (proliferate) is reduced, while MPC death is elevated in MPCs from healthy older adults. Further, the investigators have demonstrated that impaired nutrient metabolism, cellular inflammation, and oxidative stress are key mechanisms in this age-related disruption of MPC proliferation and overall skeletal muscle health. Therapies that improve the regenerative process and nutrient metabolism as well as attenuate oxidative stress and inflammation are necessary to improve overall skeletal muscle health of older adults. Blueberries have properties that the investigators hypothesize will improve the proliferative capacity (increase cell division and reduce cell death) of MPCs. Additionally, the investigators hypothesize that consumption of blueberries will improve skeletal muscle regeneration in the aging population via improved nutrient metabolism, attenuated cellular inflammation, and reduction of oxidative stress. The hypotheses will be tested using a dietary blueberry intervention. Serum from our human subjects \[blueberry enriched diet (BED)-serum\] will be collected
Interventions
- DIETARY_SUPPLEMENT Blueberry enriched diet
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2017-09-29 |
| Est. Completion | 2019-12-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04262258
The ClinicalTrials.gov registry entry for NCT04262258 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 22 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cornell University, which has 66 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Blueberry enriched diet is the first listed.
NCT04262258 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04262258 about?
NCT04262258 is a clinical study titled "Effects of a Blueberry Enriched Diet on the Skeletal Muscle Regenerative Process". One of the greatest challenges faced by older adults is maintaining physical function and strength with aging. Deterioration of skeletal muscle with aging leads to loss of mobility, decreased quality of life, and ultimately loss of independence. Skeletal muscle deterioration with aging is multifacto...
What is the current status of trial NCT04262258?
This trial is currently completed. It is a NA study. The enrollment target is 22 participants. The study started on 2017-09-29. Estimated completion is 2019-12-31.
What interventions are being tested in trial NCT04262258?
The interventions under investigation include: Blueberry enriched diet (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT04262258?
This trial is sponsored by Cornell University, which has 66 total clinical trials registered on ClinicalTrials.gov.
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