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Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation
NCT04258891 · View on ClinicalTrials.gov ↗
Study Summary
The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction models have been derived in the past years, none of these models are dynamic: they do not integrate the repeated measurements recorded throughout individuals' follow-up. As highlighted in several studies, kidney function repeated measurements (i.e., trajectories) are highly associated with graft survival after kidney transplantation. The investigators made the hypothesis that these trajectories may bring relevant information in the context of graft survival risk prediction model. Hence, combining these trajectories with standard graft survival risk factors may enhance prediction performance. This could permit to derive a robust tool that could be updated over time by continuously capturing patient' personal evolution.
Conditions Studied
Interventions
- OTHER No intervention
Study Locations (18)
Other
- Unidad de Trasplante Renopáncreas, Centro de Educación Médica e Investigaciones Clínicas — Buenos Aires
- Universidade Federal de São Paulo, Hospital do Rim, Escola Paulista de Medicina — São Paulo
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Renal Transplantation Service — São Paulo
- Clinica Alemana de Santiago — Santiago
- Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, School od Medicine University of Zagreb — Zagreb
- Department of Nephrology, Centre Hospitalier Universitaire de Montpellier — Montpellier
- Nephrology Dialysis Transplantation Department, University of Lorraine, Centre Hospitalier Universitaire de Nancy — Nancy
- Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris — Paris
- Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris — Paris
- Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Foch — Suresnes
- Department of Nephrology and Organ Transplantation, Centre Hospitalier Universitaire Rangueil — Toulouse
- Bretonneau Hospital, Nephrology and Immunology Department — Tours
- Department of Nephrology, Hospital del Mar — Barcelona
California
- Department of Medicine, Division of Nephrology, Comprehensive Transplant Center, Cedars Sinai Medical Center — Los Angeles
Illinois
- Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University — Chicago
Maryland
- Department of Surgery, Johns Hopkins University School of Medicine — Baltimore
Minnesota
- William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic — Rochester
New York
- Albert Einstein College of Medicine, Renal Division Montefiore Medical Center, Kidney Transplantation Program — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14,000 participants |
| Start Date | 2004-01-01 |
| Est. Completion | 2020-06-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04258891
The ClinicalTrials.gov registry entry for NCT04258891 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 14,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Paris Translational Research Center for Organ Transplantation, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Kidney Transplant Failure appearing as the primary indexed condition, and to 1 intervention — of which No intervention is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04258891 reports 18 study locations spanning 6 distinct geographic areas — top geographies include Other, California, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04258891 about?
NCT04258891 is a clinical study titled "Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation". The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction mo...
What is the current status of trial NCT04258891?
This trial is currently completed. The enrollment target is 14,000 participants. The study started on 2004-01-01. Estimated completion is 2020-06-30.
What conditions does trial NCT04258891 study?
This clinical trial studies the following conditions: Kidney Transplant Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04258891?
The interventions under investigation include: No intervention (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04258891?
This trial is sponsored by Paris Translational Research Center for Organ Transplantation, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04258891 being conducted?
This trial has 18 study locations across California, Illinois, Maryland, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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