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NCT04258891 · ClinicalTrials.gov registry record
Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation
A clinical trial of Kidney Transplant Failure, sponsored by Paris Translational Research Center for Organ Transplantation.
- Completed
- Registry status
- 14,000
- Enrollment target
- 18
- Study locations
NCT04258891: Completed study of Kidney Transplant Failure, sponsored by Paris Translational Research Center for Organ Transplantation.
NCT04258891 is a study of Kidney Transplant Failure that has completed, run by Paris Translational Research Center for Organ Transplantation. The registered enrollment target is 14,000 participants. The trial reports 18 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04258891, a study of Kidney Transplant Failure, has completed, sponsored by Paris Translational Research Center for Organ Transplantation.
- COMPLETED
- Registry status
- 14,000 participants
- Enrollment target
- 18
- Study locations
Study Summary
The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction models have been derived in the past years, none of these models are dynamic: they do not integrate the repeated measurements recorded throughout individuals' follow-up. As highlighted in several studies, kidney function repeated measurements (i.e., trajectories) are highly associated with graft survival after kidney transplantation. The investigators made the hypothesis that these trajectories may bring relevant information in the context of graft survival risk prediction model. Hence, combining these trajectories with standard graft survival risk factors may enhance prediction performance. This could permit to derive a robust tool that could be updated over time by continuously capturing patient' personal evolution.
Primary Outcome
Allograft survival probability, calculated from a dynamic prediction system, based on clinical, histological, immunological and estimated glomerular filtration rate and proteinuria repeated measurements, assessed at the time of risk evaluation and that can be updated thereafter.
Conditions Studied
Interventions
- OTHER No intervention
Study Locations (18)
Other
- Unidad de Trasplante Renopáncreas, Centro de Educación Médica e Investigaciones Clínicas - Buenos Aires
- Universidade Federal de São Paulo, Hospital do Rim, Escola Paulista de Medicina - São Paulo
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Renal Transplantation Service - São Paulo
- Clinica Alemana de Santiago - Santiago
- Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, School od Medicine University of Zagreb - Zagreb
- Department of Nephrology, Centre Hospitalier Universitaire de Montpellier - Montpellier
- Nephrology Dialysis Transplantation Department, University of Lorraine, Centre Hospitalier Universitaire de Nancy - Nancy
- Kidney Transplant Department, Saint-Louis Hospital, Assistance Publique - Hôpitaux de Paris - Paris
- Kidney Transplant Department, Necker Hospital, Assistance Publique - Hôpitaux de Paris - Paris
- Department of Transplantation, Nephrology and Clinical Immunology, Hôpital Foch - Suresnes
- Department of Nephrology and Organ Transplantation, Centre Hospitalier Universitaire Rangueil - Toulouse
- Bretonneau Hospital, Nephrology and Immunology Department - Tours
- Department of Nephrology, Hospital del Mar - Barcelona
California
- Department of Medicine, Division of Nephrology, Comprehensive Transplant Center, Cedars Sinai Medical Center - Los Angeles
Illinois
- Division of Transplantation, Department of Surgery, Feinberg School of Medicine, Northwestern University - Chicago
Maryland
- Department of Surgery, Johns Hopkins University School of Medicine - Baltimore
Minnesota
- William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic - Rochester
New York
- Albert Einstein College of Medicine, Renal Division Montefiore Medical Center, Kidney Transplantation Program - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14,000 participants |
| Start Date | 2004-01-01 |
| Est. Completion | 2020-06-30 |
What the finished NCT04258891 record still lists
NCT04258891 is an observational study that tracks outcomes without assigning an intervention. Its 14,000 participants enrollment target places it among the larger protocols in the corpus.
The record links to 1 condition, with Kidney Transplant Failure appearing as the primary indexed condition, and to 1 intervention - of which No intervention is the first listed.
NCT04258891 lists 18 locations in 6 states (Other, California, Illinois).
Frequently Asked Questions
What is clinical trial NCT04258891 about?
NCT04258891 is a clinical study titled "Multidimensional System to Dynamically Predict Graft Survival After Kidney Transplantation". The incidence of end stage renal disease (ESRD) is rapidly increasing, now affecting an estimated 7.4 million people worldwide. Numerous parameters such as demographic, clinical and functional factors drive the deterioration of the kidney, ultimately leading to ESRD. Although some ESRD prediction mo...
What is the current status of trial NCT04258891?
This trial is currently completed. The enrollment target is 14,000 participants. The study started on 2004-01-01. Estimated completion is 2020-06-30.
What conditions does trial NCT04258891 study?
This clinical trial studies the following conditions: Kidney Transplant Failure.
What interventions are being tested in trial NCT04258891?
The interventions under investigation include: No intervention (OTHER).
Who is sponsoring clinical trial NCT04258891?
This trial is sponsored by Paris Translational Research Center for Organ Transplantation, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04258891 being conducted?
This trial has 18 study locations across California, Illinois, Maryland, Minnesota, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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