Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma

NCT04246047 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 3, randomized, open-label study designed to evaluate safety and efficacy of belantamab mafodotin in combination with bortezomib/dexamethasone (Arm A) versus daratumumab in combination with bortezomib/dexamethasone (Arm B) in the participants with relapsed recurrent multiple myeloma.

Conditions Studied

Interventions

  • DRUG Belantamab mafodotin
  • DRUG Dexamethasone
  • DRUG Daratumumab
  • DRUG Bortezomib

Study Locations (20)

New South Wales

  • GSK Investigational Site — Camperdown
  • GSK Investigational Site — Liverpool
  • GSK Investigational Site — St Leonards
  • GSK Investigational Site — Waratah
  • GSK Investigational Site — Wollongong

Victoria

  • GSK Investigational Site — Box Hill
  • GSK Investigational Site — Heidelberg
  • GSK Investigational Site — Melbourne

Queensland

  • GSK Investigational Site — Benowa
  • GSK Investigational Site — Herston

Western Australia

  • GSK Investigational Site — Murdoch
  • GSK Investigational Site — Nedlands

Arizona

  • GSK Investigational Site — Yuma

Colorado

  • GSK Investigational Site — Denver

Connecticut

  • GSK Investigational Site — Fairfield

Kansas

  • GSK Investigational Site — Kansas City

Trial Details

FieldValue
Enrollment Target 494 participants
Start Date 2020-05-07
Est. Completion 2026-06-19
Phase Phase 3

Sponsor

GlaxoSmithKline

558 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04246047

The ClinicalTrials.gov registry entry for NCT04246047 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 494 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is GlaxoSmithKline, which has 558 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Belantamab mafodotin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04246047 reports 20 study locations spanning 12 distinct geographic areas — top geographies include New South Wales, Victoria, Queensland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04246047 about?

NCT04246047 is a clinical study titled "Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma". This is a Phase 3, randomized, open-label study designed to evaluate safety and efficacy of belantamab mafodotin in combination with bortezomib/dexamethasone (Arm A) versus daratumumab in combination with bortezomib/dexamethasone (Arm B) in the participants with relapsed recurrent multiple myeloma.

What is the current status of trial NCT04246047?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 494 participants. The study started on 2020-05-07. Estimated completion is 2026-06-19.

What conditions does trial NCT04246047 study?

This clinical trial studies the following conditions: Multiple Myeloma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04246047?

The interventions under investigation include: Belantamab mafodotin (DRUG), Dexamethasone (DRUG), Daratumumab (DRUG), Bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04246047?

This trial is sponsored by GlaxoSmithKline, which has 558 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04246047 being conducted?

This trial has 20 study locations across Arizona, Colorado, Connecticut, Kansas, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial