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NCT04234919 · ClinicalTrials.gov registry record
Longitudinal Study of Cell Free DNA in Lung Transplant
A clinical trial, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- 24
- Enrollment target
NCT04234919: Completed study, sponsored by University of Colorado, Denver.
NCT04234919 is a clinical trial that has completed, run by University of Colorado, Denver. The registered enrollment target is 24 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04234919 has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- 24 participants
- Enrollment target
Study Summary
Lung transplant is a viable treatment strategy for many with end-stage lung diseases. Despite advances in both the surgical and medical management, lung transplant recipients experience episodes of allograft insult and injury that lead to dysfunction and ultimately contribute to graft failure. The primary noninvasive tool for monitoring the lung allograft, pulmonary function testing, is neither sensitive nor specific for lung allograft injury which makes the management of lung transplant recipients particularly challenging. A decline in pulmonary function tests prompts invasive procedures such as bronchoscopy with transbronchial lung biopsy to diagnose the cause of allograft injury, although this, too, is not 100% sensitive, and oftentimes patients are treated empirically for rejection when no other etiology for lung function decline is identified. Empiric treatment prompted by extrapulmonary drivers of decline in lung function may result in inappropriate exposure to risks of augmented immunosuppression. The purpose of this study is to determine to what extent monitoring of donor-derived cell free DNA in lung transplant recipients can be used as a marker of lung injury and stability.
Primary Outcome
Determine the relationship between donor derived cell free DNA and lung allograft function during the first year after lung transplant.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2020-03-19 |
| Est. Completion | 2021-11-22 |
What the finished NCT04234919 record still lists
NCT04234919 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 24 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT04234919 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04234919 about?
NCT04234919 is a clinical study titled "Longitudinal Study of Cell Free DNA in Lung Transplant". Lung transplant is a viable treatment strategy for many with end-stage lung diseases. Despite advances in both the surgical and medical management, lung transplant recipients experience episodes of allograft insult and injury that lead to dysfunction and ultimately contribute to graft failure. The p...
What is the current status of trial NCT04234919?
This trial is currently completed. The enrollment target is 24 participants. The study started on 2020-03-19. Estimated completion is 2021-11-22.
Who is sponsoring clinical trial NCT04234919?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
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