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NCT04209946 · ClinicalTrials.gov registry record · NA
Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants
A NA study, sponsored by Sharp HealthCare.
- Completed
- Registry status
- NA
- Development phase
- 180
- Enrollment target
NCT04209946: Completed NA study, sponsored by Sharp HealthCare.
NCT04209946 is a NA study that has completed, run by Sharp HealthCare. The registered enrollment target is 180 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04209946, a NA study, has completed, sponsored by Sharp HealthCare.
- COMPLETED
- Registry status
- NA
- Development phase
- 180 participants
- Enrollment target
Study Summary
This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life when compared to early Continuous Positive Airway Pressure (CPAP) alone.
Primary Outcome
Required intubation or meeting respiratory failure criteria of having a pCO2 greater than 65 mm Hg or an FiO2 greater than 0.4 for more than 2 hours in the first 72 hours of life
Interventions
- PROCEDURE Less Invasive Surfactant Administration LISA
- PROCEDURE Continuous Positive Airway Pressure CPAP
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2020-01-22 |
| Est. Completion | 2025-11-10 |
| Phase | NA |
What the finished NCT04209946 record still lists
NCT04209946 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 2 interventions - of which Less Invasive Surfactant Administration LISA is the first listed.
NCT04209946 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04209946 about?
NCT04209946 is a clinical study titled "Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants". This study is being conducted to determine whether prophylactic administration of surfactant by the Less Invasive Surfactant Administration (LISA) method reduces the need for mechanical ventilation in the first 72 hours of life when compared to early Continuous Positive Airway Pressure (CPAP) alone.
What is the current status of trial NCT04209946?
This trial is currently completed. It is a NA study. The enrollment target is 180 participants. The study started on 2020-01-22. Estimated completion is 2025-11-10.
What interventions are being tested in trial NCT04209946?
The interventions under investigation include: Less Invasive Surfactant Administration LISA (PROCEDURE), Continuous Positive Airway Pressure CPAP (PROCEDURE).
Who is sponsoring clinical trial NCT04209946?
This trial is sponsored by Sharp HealthCare, which has 32 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04209946's enrollment target sits among peer trials
180 586th of 2000 higher than 1,397 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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