Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04178967 · ClinicalTrials.gov registry record · Phase 3
Evaluation of the Efficacy and Safety of Lebrikizumab (LY3650150) in Moderate to Severe Atopic Dermatitis
A Phase 3 study of Atopic Dermatitis, sponsored by Eli Lilly and Company.
- Completed
- Registry status
- Phase 3
- Development phase
- 445
- Enrollment target
- 20
- Study locations
NCT04178967: Completed Phase 3 study of Atopic Dermatitis, sponsored by Eli Lilly and Company.
NCT04178967 is a Phase 3 study of Atopic Dermatitis that has completed, run by Eli Lilly and Company. The registered enrollment target is 445 participants, below the 606-participant average among 150 other Atopic Dermatitis trials with a reported enrollment target (27% lower). The trial reports 20 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04178967, a Phase 3 study of Atopic Dermatitis, has completed, sponsored by Eli Lilly and Company.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 445 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a randomized, double-blind, placebo-controlled, parallel-group study which is 52 weeks in duration. The study is designed to confirm the safety and efficacy of lebrikizumab as monotherapy for treatment of moderate-to-severe atopic dermatitis utilizing a 16-week induction treatment period and a 36-week long-term maintenance treatment period.
Primary Outcome
The IGA measures the investigator's global assessment of the participant's overall severity of their atopic dermatitis (AD), based on a static, numeric 5-point scale from 0 (clear skin) to 4 (severe disease). The score is based on an overall assessment of the degree of erythema, papulation/induration, oozing/crusting, and lichenification.
Conditions Studied
Interventions
- OTHER Placebo
- BIOLOGICAL Lebrikizumab
Study Locations (20)
California
- Bakersfield Dermatology and Skin Cancer Medical Group - Bakersfield
- Center For Dermatology Clinical Research, Inc. - Fremont
- Woodward Centre - Fresno
- Dermatology Research Associates - Los Angeles
- LA Universal Research Center, INC - Los Angeles
- University Clinical Trials, Inc. - San Diego
- San Luis Dermatology & Laser Clinic - San Luis Obispo
Florida
- Clinical Physiology Associates, Clinical Study Center - Fort Myers
- Direct Helpers Medical Center - Hialeah
- The Community Research of South Florida - Hialeah
- Solutions Through Advanced Research, Inc. - Jacksonville
Georgia
- Georgia Pollens Clinical Research Centers, Inc - Albany
- Marietta Dermatology Clinical Research - Marietta
- Advanced Medical Research - Sandy Springs
Illinois
- Arlington Dermatology - Rolling Meadows
- NorthShore University HealthSystem - Skokie
Arizona
- Investigate MD - Scottsdale
Arkansas
- Northwest Arkansas Clinical Trials Center - Rogers
Kansas
- Kansas City Dermatology, PA - Overland Park
Louisiana
- Meridian Clinical Research - Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 445 participants |
| Start Date | 2019-10-29 |
| Est. Completion | 2022-04-28 |
| Phase | Phase 3 |
What the finished NCT04178967 record still lists
NCT04178967 is an interventional study that assigns participants to a tested intervention. The registered 445 participants enrollment target is mid-sized for trials with a published cap, below the 606-participant average among 150 other Atopic Dermatitis trials with a reported enrollment target (27% lower).
The record links to 1 condition, with Atopic Dermatitis appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04178967 names 20 study sites across 8 states, led by California, Florida, Georgia.
Frequently Asked Questions
What is clinical trial NCT04178967 about?
NCT04178967 is a clinical study titled "Evaluation of the Efficacy and Safety of Lebrikizumab (LY3650150) in Moderate to Severe Atopic Dermatitis". This is a randomized, double-blind, placebo-controlled, parallel-group study which is 52 weeks in duration. The study is designed to confirm the safety and efficacy of lebrikizumab as monotherapy for treatment of moderate-to-severe atopic dermatitis utilizing a 16-week induction treatment period and...
What is the current status of trial NCT04178967?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 445 participants. The study started on 2019-10-29. Estimated completion is 2022-04-28.
What conditions does trial NCT04178967 study?
This clinical trial studies the following conditions: Atopic Dermatitis.
What interventions are being tested in trial NCT04178967?
The interventions under investigation include: Placebo (OTHER), Lebrikizumab (BIOLOGICAL).
Who is sponsoring clinical trial NCT04178967?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04178967 being conducted?
This trial has 20 study locations across Arizona, Arkansas, California, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Atopic Dermatitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04178967's enrollment target sits among peer trials
445 28th of 150 higher than 123 of 150 other Atopic Dermatitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Atopic Dermatitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis
RECRUITING · Phase 3
-
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe Eczema
RECRUITING · Phase 3
-
A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis
RECRUITING · Phase 3
-
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis
RECRUITING · Phase 3
-
A Study to Assess the Efficacy and Safety of Ruxolitinib Cream in Children and Adolescents (6 to <18 Years Old) With Moderate Atopic Dermatitis
RECRUITING · Phase 3
-
A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab
RECRUITING · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01280994 · 445 participants · Phase 2
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
- NCT03504800 · 445 participants
OCT in Diagnosis of Irregular Corneas
- NCT04751435 · 445 participants · NA
Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
- NCT06348394 · 444 participants · NA
Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI