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NCT04159831 · ClinicalTrials.gov registry record · Phase 2
A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions
A Phase 2 study, sponsored by Rein Therapeutics.
- Completed
- Registry status
- Phase 2
- Development phase
- 44
- Enrollment target
NCT04159831: Completed Phase 2 study, sponsored by Rein Therapeutics.
NCT04159831 is a Phase 2 study that has completed, run by Rein Therapeutics. The registered enrollment target is 44 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04159831, a Phase 2 study, has completed, sponsored by Rein Therapeutics.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 44 participants
- Enrollment target
Study Summary
The LTI-01-2001 study is a double-blind, placebo-controlled, Phase 2 study to evaluate LTI-01 (single-chain urokinase plasminogen activator, scuPA) in patients with infected, non-draining pleural effusions.
Primary Outcome
Treatment failure, as evidenced by continued or worsening pleural sepsis and failure to adequately drain pleural effusion, resulting in referral to surgery
Interventions
- DRUG Placebo
- DRUG LTI-01
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 44 participants |
| Start Date | 2020-09-26 |
| Est. Completion | 2022-07-28 |
| Phase | Phase 2 |
What the finished NCT04159831 record still lists
NCT04159831 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 44 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT04159831 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04159831 about?
NCT04159831 is a clinical study titled "A Study to Evaluate LTI-01 in Patients With Infected, Non-draining Pleural Effusions". The LTI-01-2001 study is a double-blind, placebo-controlled, Phase 2 study to evaluate LTI-01 (single-chain urokinase plasminogen activator, scuPA) in patients with infected, non-draining pleural effusions.
What is the current status of trial NCT04159831?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 44 participants. The study started on 2020-09-26. Estimated completion is 2022-07-28.
What interventions are being tested in trial NCT04159831?
The interventions under investigation include: Placebo (DRUG), LTI-01 (DRUG).
Who is sponsoring clinical trial NCT04159831?
This trial is sponsored by Rein Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04159831's enrollment target sits among peer trials
44 1322nd of 2000 higher than 669 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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