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NCT04155658 · ClinicalTrials.gov registry record · NA
Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation
A NA study, sponsored by Unilever R&D.
- Completed
- Registry status
- NA
- Development phase
- 55
- Enrollment target
NCT04155658: Completed NA study, sponsored by Unilever R&D.
NCT04155658 is a NA study that has completed, run by Unilever R&D. The registered enrollment target is 55 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04155658, a NA study, has completed, sponsored by Unilever R&D.
- COMPLETED
- Registry status
- NA
- Development phase
- 55 participants
- Enrollment target
Study Summary
Double-blind, randomized, 3 group in situ study to assess effect of three toothpastes on enamel remineralization, as measured by change in integrated mineral loss (∆∆Z). The study will examine the efficacy of an experimental sodium monofluorophosphate (SMFP) toothpaste, a standard SMFP toothpaste and a negative control toothpaste with no fluoride.
Primary Outcome
Calculation of Integrated Mineral Loss ∆Z = \[(lesion depth x 87) - area under the curve\] where 'area under the curve' relates volume % mineral at distances from the enamel specimen surface with respect to enamel section thickness, measured using transverse microradiography (TMR)
Interventions
- OTHER Experimental Toothpaste containing 1450ppm SMFP
- OTHER Toothpaste containing 1450ppm SMFP
- OTHER Toothpaste with no fluoride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 55 participants |
| Start Date | 2019-11-25 |
| Est. Completion | 2020-04-30 |
| Phase | NA |
What the finished NCT04155658 record still lists
NCT04155658 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 55 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 3 interventions - of which Experimental Toothpaste containing 1450ppm SMFP is the first listed.
NCT04155658 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04155658 about?
NCT04155658 is a clinical study titled "Evaluation of Efficacy of Sodium Monofluorophosphate (SMPF) Toothpastes on Enamel Lesion Remineralisation". Double-blind, randomized, 3 group in situ study to assess effect of three toothpastes on enamel remineralization, as measured by change in integrated mineral loss (∆∆Z). The study will examine the efficacy of an experimental sodium monofluorophosphate (SMFP) toothpaste, a standard SMFP toothpaste an...
What is the current status of trial NCT04155658?
This trial is currently completed. It is a NA study. The enrollment target is 55 participants. The study started on 2019-11-25. Estimated completion is 2020-04-30.
What interventions are being tested in trial NCT04155658?
The interventions under investigation include: Experimental Toothpaste containing 1450ppm SMFP (OTHER), Toothpaste containing 1450ppm SMFP (OTHER), Toothpaste with no fluoride (OTHER).
Who is sponsoring clinical trial NCT04155658?
This trial is sponsored by Unilever R&D, which has 3 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04155658's enrollment target sits among peer trials
55 1264th of 2000 higher than 733 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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