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NCT04136873 · ClinicalTrials.gov registry record · Phase 1
A Multiple Ascending Dose Trial of CVL-231 in Subjects With Schizophrenia
A Phase 1 study, sponsored by Cerevel Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 130
- Enrollment target
NCT04136873: Completed Phase 1 study, sponsored by Cerevel Therapeutics.
NCT04136873 is a Phase 1 study that has completed, run by Cerevel Therapeutics. The registered enrollment target is 130 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (117% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04136873, a Phase 1 study, has completed, sponsored by Cerevel Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 130 participants
- Enrollment target
Study Summary
The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CVL-231 following multiple-dose oral administration in subjects with schizophrenia.
Primary Outcome
Includes Incidence of Significant ECG Abnormalities Occurring Post-Baseline, significant changes in Vital signs (Systolic and Diastolic blood pressures, heart rate, respiratory rate and body temperature), and changes in laboratory measures (hematology, serum chemistry and urinalysis)
Interventions
- DRUG Matching Placebo
- DRUG CVL-231
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2019-10-15 |
| Est. Completion | 2021-06-03 |
| Phase | Phase 1 |
What the finished NCT04136873 record still lists
NCT04136873 is an interventional study that assigns participants to a tested intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (117% higher).
The record links to 0 conditions, and to 2 interventions - of which Matching Placebo is the first listed.
NCT04136873 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04136873 about?
NCT04136873 is a clinical study titled "A Multiple Ascending Dose Trial of CVL-231 in Subjects With Schizophrenia". The aim of this trial is to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of CVL-231 following multiple-dose oral administration in subjects with schizophrenia.
What is the current status of trial NCT04136873?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 130 participants. The study started on 2019-10-15. Estimated completion is 2021-06-03.
What interventions are being tested in trial NCT04136873?
The interventions under investigation include: Matching Placebo (DRUG), CVL-231 (DRUG).
Who is sponsoring clinical trial NCT04136873?
This trial is sponsored by Cerevel Therapeutics, which has 21 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04136873's enrollment target sits among peer trials
130 439th of 2000 higher than 1,550 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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