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NCT04124354 · ClinicalTrials.gov registry record · NA
Influence of Exercise on the Gut Microbiome of Overweight and Obese Adults With Prediabetes
A NA study, sponsored by University of Minnesota.
- Terminated
- Registry status
- NA
- Development phase
- 4
- Enrollment target
NCT04124354: Clinical Trial NA study, sponsored by University of Minnesota.
NCT04124354 is a NA study that was terminated before completion, run by University of Minnesota. The registered enrollment target is 4 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04124354, a NA study, was terminated before completion, sponsored by University of Minnesota.
- TERMINATED
- Registry status
- NA
- Development phase
- 4 participants
- Enrollment target
Study Summary
Purpose: The investigators propose a 20-participant randomized 2-arm parallel trial with a delayed-intervention control examining how 8 weeks of moderate-intensity walking exercise alters the gut microbiome, short chain fatty acid (SCFA)-producing taxa, and the cardiometabolic profile and body weight of individuals who are overweight or obese and have prediabetes (PreD). Aim 1: Examine and compare exercise-related shifts in the gut microbiome of individuals with PreD. Aim 2: Examine and compare exercise-related changes in SCFA-producing taxa. Exploratory Aim: Examine what percentage of the exercise-related changes observed in participants' gut microbiome and SCFA-producing taxa mediate changes in their cardiometabolic profile and body weight.
Primary Outcome
Alpha diversity is the mean species diversity of a local site, which, in this study, is the fecal sample provided by participants used as a proxy for sampling the gut microbiome. The Shannon Index is based on the weighted geometric mean of the proportional abundances of the types of microbes. Change in alpha diversity will be reported as change in operational taxonomic units (OTUs).
Interventions
- BEHAVIORAL Physical Activity
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4 participants |
| Start Date | 2020-02-10 |
| Est. Completion | 2020-08-31 |
| Phase | NA |
Why NCT04124354 stopped before completion
NCT04124354 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (100% lower).
The record links to 0 conditions, and to 1 intervention - of which Physical Activity is the first listed.
NCT04124354 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04124354 about?
NCT04124354 is a clinical study titled "Influence of Exercise on the Gut Microbiome of Overweight and Obese Adults With Prediabetes". Purpose: The investigators propose a 20-participant randomized 2-arm parallel trial with a delayed-intervention control examining how 8 weeks of moderate-intensity walking exercise alters the gut microbiome, short chain fatty acid (SCFA)-producing taxa, and the cardiometabolic profile and body weigh...
What is the current status of trial NCT04124354?
This trial is currently terminated. It is a NA study. The enrollment target is 4 participants. The study started on 2020-02-10. Estimated completion is 2020-08-31.
What interventions are being tested in trial NCT04124354?
The interventions under investigation include: Physical Activity (BEHAVIORAL).
Who is sponsoring clinical trial NCT04124354?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04124354's enrollment target sits among peer trials
4 1996th of 2000 higher than 5 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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