Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04104685 · ClinicalTrials.gov registry record · Phase 2
A Study to Compare FCD105 Foam to Minocycline 3% Foam, Adapalene 0.3% Foam and Vehicle Foam.
A Phase 2 study, sponsored by Vyne Therapeutics.
- Completed
- Registry status
- Phase 2
- Development phase
- 446
- Enrollment target
NCT04104685: Completed Phase 2 study, sponsored by Vyne Therapeutics.
NCT04104685 is a Phase 2 study that has completed, run by Vyne Therapeutics. The registered enrollment target is 446 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (235% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04104685, a Phase 2 study, has completed, sponsored by Vyne Therapeutics.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 446 participants
- Enrollment target
Study Summary
A study comparing FCD105 to 3% minocycline foam, 0.3% adapalene foam and vehicle foam in patients ≥ 12 years old for the treatment of moderate-to-severe acne.
Primary Outcome
Statistical superiority of FCD105 vs. vehicle in the absolute change from Baseline in inflammatory lesion counts at Visit 4 (Week12/End of Treatment)
Interventions
- COMBINATION_PRODUCT FCD105
- DRUG 3% Minocycline Foam
- DRUG 0.3% Adapalene Foam
- OTHER Vehicle Foam
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 446 participants |
| Start Date | 2019-09-18 |
| Est. Completion | 2020-03-03 |
| Phase | Phase 2 |
What the finished NCT04104685 record still lists
NCT04104685 is an interventional study that assigns participants to a tested intervention. The registered 446 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (235% higher).
The record links to 0 conditions, and to 4 interventions - of which FCD105 is the first listed.
NCT04104685 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04104685 about?
NCT04104685 is a clinical study titled "A Study to Compare FCD105 Foam to Minocycline 3% Foam, Adapalene 0.3% Foam and Vehicle Foam.". A study comparing FCD105 to 3% minocycline foam, 0.3% adapalene foam and vehicle foam in patients ≥ 12 years old for the treatment of moderate-to-severe acne.
What is the current status of trial NCT04104685?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 446 participants. The study started on 2019-09-18. Estimated completion is 2020-03-03.
What interventions are being tested in trial NCT04104685?
The interventions under investigation include: FCD105 (COMBINATION_PRODUCT), 3% Minocycline Foam (DRUG), 0.3% Adapalene Foam (DRUG), Vehicle Foam (OTHER).
Who is sponsoring clinical trial NCT04104685?
This trial is sponsored by Vyne Therapeutics, which has 18 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04104685's enrollment target sits among peer trials
446 89th of 2000 higher than 1,912 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04065399 · 447 participants · Phase 1
A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation
- NCT01280994 · 445 participants · Phase 2
Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
- NCT03504800 · 445 participants
OCT in Diagnosis of Irregular Corneas
- NCT04751435 · 445 participants · NA
Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI