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Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
NCT04095663 · View on ClinicalTrials.gov ↗
Study Summary
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease, is elective colectomy more effective than best medical management? The hypothesis being tested in the COSMID trial is that patient-reported outcomes (PROs) among patients in the surgery arm will be superior to those in the best medical management arm.
Conditions Studied
Interventions
- OTHER Medical Management
- PROCEDURE Partial Colectomy
Study Locations (20)
New York
- Albany Medical College — Albany
- New York Presbyterian-Queens — Flushing
- Columbia University Medical Center — New York
- Weill Cornell Medicine — New York
- University of Rochester Medical Center — Rochester
California
- Cedars-Sinai Medical Center — Los Angeles
- UC San Diego Health — San Diego
- UCSF Health — San Francisco
- Stanford University Medical Center — Stanford
Florida
- University of Florida — Gainesville
- University of South Florida — Tampa
Illinois
- Rush University Medical Center — Chicago
- Northwestern University — Evanston
Massachusetts
- Boston University Medical Center — Boston
- Lahey Clinic — Burlington
Colorado
- University of Colorado — Denver
Georgia
- Memorial Health University Medical Center — Savannah
Iowa
- University of Iowa Healthcare — Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2027-02-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04095663
The ClinicalTrials.gov registry entry for NCT04095663 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 255 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 987 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Diverticulitis appearing as the primary indexed condition, and to 2 interventions — of which Medical Management is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04095663 reports 20 study locations spanning 10 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04095663 about?
NCT04095663 is a clinical study titled "Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial". The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort wi...
What is the current status of trial NCT04095663?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 255 participants. The study started on 2019-10-01. Estimated completion is 2027-02-01.
What conditions does trial NCT04095663 study?
This clinical trial studies the following conditions: Diverticulitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04095663?
The interventions under investigation include: Medical Management (OTHER), Partial Colectomy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04095663?
This trial is sponsored by University of Washington, which has 987 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04095663 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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