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NCT04095663 · ClinicalTrials.gov registry record · NA
Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial
A NA study of Diverticulitis, sponsored by University of Washington.
- Active
- Registry status
- NA
- Development phase
- 255
- Enrollment target
- 20
- Study locations
NCT04095663: Active NA study of Diverticulitis, sponsored by University of Washington.
NCT04095663 is a NA study of Diverticulitis that is active but no longer recruiting, run by University of Washington. The registered enrollment target is 255 participants, below the 25,204-participant average among 8 other Diverticulitis trials with a reported enrollment target (99% lower). The trial reports 20 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04095663, a NA study of Diverticulitis, is active but no longer recruiting, sponsored by University of Washington.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 255 participants
- Enrollment target
- 20
- Study locations
Study Summary
The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort will include those who are disinclined to have their treatment choice randomized, but are willing to contribute information about their outcomes. The goal of the COSMID trial is to answer the question: For patients with QoL-limiting diverticular disease, is elective colectomy more effective than best medical management? The hypothesis being tested in the COSMID trial is that patient-reported outcomes (PROs) among patients in the surgery arm will be superior to those in the best medical management arm.
Primary Outcome
A 36-item questionnaire assessing 5 domains: GI symptoms, physical function, emotional well-being, social well-being, and perception of medical treatment measured by a single item question. Each item has 5 response choices (i.e., all of the time, most of the time, some of the time, a little of the time, never). In addition, the measure produces an overall quality of life score (0-144) where higher numbers indicate greater QoL.
Conditions Studied
Interventions
- OTHER Medical Management
- PROCEDURE Partial Colectomy
Study Locations (20)
New York
- Albany Medical College - Albany
- New York Presbyterian-Queens - Flushing
- Columbia University Medical Center - New York
- Weill Cornell Medicine - New York
- University of Rochester Medical Center - Rochester
California
- Cedars-Sinai Medical Center - Los Angeles
- UC San Diego Health - San Diego
- UCSF Health - San Francisco
- Stanford University Medical Center - Stanford
Florida
- University of Florida - Gainesville
- University of South Florida - Tampa
Illinois
- Rush University Medical Center - Chicago
- Northwestern University - Evanston
Massachusetts
- Boston University Medical Center - Boston
- Lahey Clinic - Burlington
Colorado
- University of Colorado - Denver
Georgia
- Memorial Health University Medical Center - Savannah
Iowa
- University of Iowa Healthcare - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2027-02-01 |
| Phase | NA |
What the registry record for NCT04095663 still lists
NCT04095663 is an interventional study that assigns participants to a tested intervention. The registered 255 participants enrollment target is mid-sized for trials with a published cap, below the 25,204-participant average among 8 other Diverticulitis trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Diverticulitis appearing as the primary indexed condition, and to 2 interventions - of which Medical Management is the first listed.
NCT04095663 names 20 study sites across 10 states, led by New York, California, Florida.
Frequently Asked Questions
What is clinical trial NCT04095663 about?
NCT04095663 is a clinical study titled "Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial". The COSMID (Comparison of Surgery and Medicine on the Impact of Diverticulitis) trial is a pragmatic, patient-level randomized superiority trial of elective colectomy vs. best medical management for patients with quality of life (QoL) limiting diverticular disease. A parallel observational cohort wi...
What is the current status of trial NCT04095663?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 255 participants. The study started on 2019-10-01. Estimated completion is 2027-02-01.
What conditions does trial NCT04095663 study?
This clinical trial studies the following conditions: Diverticulitis.
What interventions are being tested in trial NCT04095663?
The interventions under investigation include: Medical Management (OTHER), Partial Colectomy (PROCEDURE).
Who is sponsoring clinical trial NCT04095663?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04095663 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diverticulitis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04095663's enrollment target sits among peer trials
255 4th of 8 higher than 5 of 8 other Diverticulitis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diverticulitis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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