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NCT04078035 · ClinicalTrials.gov registry record · NA
Biological Response to Brief Psychological Challenge
A NA study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 72
- Enrollment target
NCT04078035 is a NA study that has completed, run by University of Pittsburgh. The registered enrollment target is 72 participants.
The verdict
NCT04078035, a NA study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
Study Summary
The investigators plan to conduct a crossover experimental trial examining physiological responses to a socio-evaluative speech task under laboratory conditions. Participants will attend two laboratory sessions. At one session participants will take part in a brief laboratory stress task and at the other participants will rest for the same period. Measures of cardiovascular response will be assessed at both sessions. In addition, blood will be drawn at multiple time points across a 125 minute period to assess changes in circulating levels of cortisol, catecholamines, markers of inflammation and cell free mitochondrial DNA in response to the task. The investigators expect that the stress task will induce a specific increase in ccf-mtDNA, which will statistically mediate subsequent peak circulating Interleukin-6 and Tumor Necrosis Factor-α levels. In secondary analyses, the investigators will examine whether stress-induced increases in circulating cortisol, epinephrine, and norepinephrine levels correlate with increases in ccf-mtDNA. These studies will establish the kinetics and magnitude of psychological stress-induced ccf-mtDNA release, the association with early stress mediators, and whether ccf-mtDNA mediates the inflammatory response to acute stress in humans.
Interventions
- BEHAVIORAL Socio-evaluative speech task
- BEHAVIORAL Control, Quiet Rest
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2020-07-23 |
| Est. Completion | 2022-01-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04078035
The ClinicalTrials.gov registry entry for NCT04078035 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 72 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Socio-evaluative speech task is the first listed.
NCT04078035 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT04078035 about?
NCT04078035 is a clinical study titled "Biological Response to Brief Psychological Challenge". The investigators plan to conduct a crossover experimental trial examining physiological responses to a socio-evaluative speech task under laboratory conditions. Participants will attend two laboratory sessions. At one session participants will take part in a brief laboratory stress task and at the ...
What is the current status of trial NCT04078035?
This trial is currently completed. It is a NA study. The enrollment target is 72 participants. The study started on 2020-07-23. Estimated completion is 2022-01-31.
What interventions are being tested in trial NCT04078035?
The interventions under investigation include: Socio-evaluative speech task (BEHAVIORAL), Control, Quiet Rest (BEHAVIORAL).
Who is sponsoring clinical trial NCT04078035?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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