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NCT04077424 · ClinicalTrials.gov registry record · Phase 4
Senescent Immunity in Elders and Vaccine Responses (SILVER)
A Phase 4 study, sponsored by Vanderbilt University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 10
- Enrollment target
NCT04077424: Completed Phase 4 study, sponsored by Vanderbilt University Medical Center.
NCT04077424 is a Phase 4 study that has completed, run by Vanderbilt University Medical Center. The registered enrollment target is 10 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04077424, a Phase 4 study, has completed, sponsored by Vanderbilt University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 10 participants
- Enrollment target
Study Summary
To study the effects of age on the immune system's response to flu vaccine and to study the connection between the immune system and physical and cognitive changes associated with aging.
Primary Outcome
2 fold dilution series of serum, and measurement of titer which inhibits hemagglutination. Titers were measured for each of 4 antigens in the vaccine (A/Brisbane/2018 (H1N1), A/Kansas/2017 (H3N2), B/Colorado/2017 (Vic), B/Phuket/2013 (Yam))
Interventions
- BIOLOGICAL Fluad
- BIOLOGICAL Fluzone-High Dose Quadrivalent
- BIOLOGICAL Flublock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2019-10-21 |
| Est. Completion | 2020-02-01 |
| Phase | Phase 4 |
What the finished NCT04077424 record still lists
NCT04077424 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 3 interventions - of which Fluad is the first listed.
NCT04077424 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04077424 about?
NCT04077424 is a clinical study titled "Senescent Immunity in Elders and Vaccine Responses (SILVER)". To study the effects of age on the immune system's response to flu vaccine and to study the connection between the immune system and physical and cognitive changes associated with aging.
What is the current status of trial NCT04077424?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 10 participants. The study started on 2019-10-21. Estimated completion is 2020-02-01.
What interventions are being tested in trial NCT04077424?
The interventions under investigation include: Fluad (BIOLOGICAL), Fluzone-High Dose Quadrivalent (BIOLOGICAL), Flublock (BIOLOGICAL).
Who is sponsoring clinical trial NCT04077424?
This trial is sponsored by Vanderbilt University Medical Center, which has 677 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04077424's enrollment target sits among peer trials
10 1940th of 2000 higher than 33 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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