Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

NCT04068597 · View on ClinicalTrials.gov ↗

Study Summary

A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 (inobrodib) in patients with Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukaemia or High Risk Myelodysplastic syndrome.

Interventions

  • DRUG Venetoclax
  • DRUG Azacitidine
  • DRUG Dexamethasone
  • DRUG Pomalidomide
  • DRUG CCS1477

Study Locations (20)

Other

  • Institute Bergonie — Bordeaux
  • Gustave Roussy — Villejuif
  • Hospital Germans Trias i Pujol/ ICO Badalona — Badalona
  • University Hospital Vall D'Hebron — Barcelona
  • Hospital Clínic de Barcelona — Barcelona
  • ICO L'Hospitalet (Instituto Catalán de Oncología) — Barcelona
  • Hospital Universitario de La Princesa — Madrid
  • Hospital Universitario Gregorio Marañón — Madrid
  • Hospital Infanta Leonor — Madrid
  • Hospital Universitario Ramón y Cajal — Madrid
  • Hospital Universitario 12 de Octubre — Madrid
  • CIOCC Hospital Universitario HM Sanchinarro — Madrid
  • Universidad de Navarra — Pamplona
  • Hospital Universitario y Politécnico La Fe de la Comunidad Valenciana — Valencia

Nebraska

  • Nebraska Cancer Specialists — Omaha
  • University of Nebraska Medical Center — Omaha

Georgia

  • Emory Winship Cancer Institute — Atlanta

Indiana

  • Community Health Network — Indianapolis

Maryland

  • The Center for Cancer and Blood Disorders (CCBD) — Bethesda

Pennsylvania

  • Penn Medicine - Abramson Cancer Center Perelman — Philadelphia

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2019-08-09
Est. Completion 2027-03-31
Phase Phase 1

Sponsor

CellCentric

1 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04068597

The ClinicalTrials.gov registry entry for NCT04068597 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is CellCentric, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 6 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 5 interventions — of which Venetoclax is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04068597 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Other, Nebraska, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04068597 about?

NCT04068597 is a clinical study titled "Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies". A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 (inobrodib) in patients with Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukaemia or High Risk Myelodysplastic syndrome.

What is the current status of trial NCT04068597?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 250 participants. The study started on 2019-08-09. Estimated completion is 2027-03-31.

What conditions does trial NCT04068597 study?

This clinical trial studies the following conditions: Multiple Myeloma, Acute Myeloid Leukemia, Non Hodgkin Lymphoma, Peripheral T Cell Lymphoma, Higher-risk Myelodysplastic Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04068597?

The interventions under investigation include: Venetoclax (DRUG), Azacitidine (DRUG), Dexamethasone (DRUG), Pomalidomide (DRUG), CCS1477 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04068597?

This trial is sponsored by CellCentric, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04068597 being conducted?

This trial has 20 study locations across Georgia, Indiana, Maryland, Nebraska, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial