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NCT04045028 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
A Phase 1 study, sponsored by Genentech.
- Terminated
- Registry status
- Phase 1
- Development phase
- 41
- Enrollment target
NCT04045028: Clinical Trial Phase 1 study, sponsored by Genentech.
NCT04045028 is a Phase 1 study that was terminated before completion, run by Genentech. The registered enrollment target is 41 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (32% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04045028, a Phase 1 study, was terminated before completion, sponsored by Genentech.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 41 participants
- Enrollment target
Study Summary
This is a Phase I open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary activity of tiragolumab administered as a single agent or in combination with atezolizumab and/or daratumumab or rituximab in participants with relapsed or refractory (R/R) multiple myeloma (MM) or R/R non-Hodgkin lymphoma (NHL).
Primary Outcome
Determined according to the NCI CTCAE Version 5.0
Interventions
- DRUG Atezolizumab
- DRUG Rituximab
- DRUG Tiragolumab
- DRUG Daratumumab/rHuPH20
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2019-07-22 |
| Est. Completion | 2023-03-28 |
| Phase | Phase 1 |
Why NCT04045028 stopped before completion
NCT04045028 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (32% lower).
The record links to 0 conditions, and to 4 interventions - of which Atezolizumab is the first listed.
NCT04045028 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04045028 about?
NCT04045028 is a clinical study titled "A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Preliminary Activity of Tiragolumab in Participants With Relapsed or Refractory Multiple Myeloma or With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma". This is a Phase I open-label, multicenter study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary activity of tiragolumab administered as a single agent or in combination with atezolizumab and/or daratumumab or rituximab in participants with relapsed ...
What is the current status of trial NCT04045028?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 41 participants. The study started on 2019-07-22. Estimated completion is 2023-03-28.
What interventions are being tested in trial NCT04045028?
The interventions under investigation include: Atezolizumab (DRUG), Rituximab (DRUG), Tiragolumab (DRUG), Daratumumab/rHuPH20 (DRUG).
Who is sponsoring clinical trial NCT04045028?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04045028's enrollment target sits among peer trials
41 1125th of 2000 higher than 871 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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