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NCT04016896 · ClinicalTrials.gov registry record · NA
Depression Prevention in Older Spousally-bereaved Adults
A NA study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 151
- Enrollment target
NCT04016896: Completed NA study, sponsored by University of Pittsburgh.
NCT04016896 is a NA study that has completed, run by University of Pittsburgh. The registered enrollment target is 151 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04016896, a NA study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 151 participants
- Enrollment target
Study Summary
Using an indicated prevention approach, investigators propose to enroll 150 spousally-bereaved adults aged 60 years and older in the first 12 months after spousal death who are at high risk for major depression disorder because of subthreshold symptoms of depression. A confirmatory efficacy trial will be conducted in which participants will be randomly assigned to (a) self-monitor sleep, meals, and physical activity for 12 weeks using digital monitoring plus motivational health coaching (WELL; n=75); or (b) enhanced usual care (EUC, usual care plus study assessments, n=75). Objective actigraphic measures of the 24-hour pattern of day and nighttime activity - known as the rest-activity rhythm - will be measured to evaluate circadian rhythms as a mediator of treatment outcomes. Participants will be assessed at baseline, months 1 \& 2, post-intervention, and 3, 6,12, 18-months post-intervention. In addition, the investigators will include a subset of participants bereaved by COVID-19 (or suspected as bereaved by COVID-19). Participants in this subset will undergo the same research procedures as the main cohort. Participants in both the main cohort and subset determined to be fully eligible will be randomized into two groups with a total of: enhanced usual care (EUC; n=75) and WELL (WELL; n=75).
Primary Outcome
Depression symptoms measured by the clinician administered Hamilton Rating Scale for Depression
Interventions
- OTHER Enhanced Usual Care
- BEHAVIORAL WIdowed Elders' LIfestyle after Loss (WELL)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 151 participants |
| Start Date | 2020-10-20 |
| Est. Completion | 2025-01-17 |
| Phase | NA |
What the finished NCT04016896 record still lists
NCT04016896 is an interventional study that assigns participants to a tested intervention. The registered 151 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which Enhanced Usual Care is the first listed.
NCT04016896 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04016896 about?
NCT04016896 is a clinical study titled "Depression Prevention in Older Spousally-bereaved Adults". Using an indicated prevention approach, investigators propose to enroll 150 spousally-bereaved adults aged 60 years and older in the first 12 months after spousal death who are at high risk for major depression disorder because of subthreshold symptoms of depression. A confirmatory efficacy trial wi...
What is the current status of trial NCT04016896?
This trial is currently completed. It is a NA study. The enrollment target is 151 participants. The study started on 2020-10-20. Estimated completion is 2025-01-17.
What interventions are being tested in trial NCT04016896?
The interventions under investigation include: Enhanced Usual Care (OTHER), WIdowed Elders' LIfestyle after Loss (WELL) (BEHAVIORAL).
Who is sponsoring clinical trial NCT04016896?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04016896's enrollment target sits among peer trials
151 661st of 2000 higher than 1,340 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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