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Salmonella Conjugates CVD 1000: Study of Responses to Vaccination With Trivalent Invasive Salmonella Disease Vaccine
NCT03981952 · View on ClinicalTrials.gov ↗
Study Summary
This is a randomized, placebo-controlled dose-escalation study. The main purpose of this research is to test the safety and measure the immune response of the trivalent vaccine against invasive Salmonella disease. The vaccine will be tested over a range of doses.
Conditions Studied
Interventions
- OTHER Placebo
- BIOLOGICAL Trivalent Invasive Salmonella Disease Vaccine (6.25 µg)
- BIOLOGICAL Trivalent Invasive Salmonella Disease Vaccine (12 µg)
- BIOLOGICAL Trivalent Invasive Salmonella Disease Vaccine (25 µg)
- BIOLOGICAL Trivalent Invasive Salmonella Disease Vaccine (highest, well-tolerated dose among Cohorts A-C)
Study Locations (1)
Maryland
- University of Maryland, Baltimore, Center for Vaccine Development and Global Health — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2019-10-28 |
| Est. Completion | 2021-05-07 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03981952
The ClinicalTrials.gov registry entry for NCT03981952 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 96 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Maryland, Baltimore, which has 559 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Risk Reduction appearing as the primary indexed condition, and to 5 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03981952 reports 1 study location spanning 1 distinct geographic area — top geographies include Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03981952 about?
NCT03981952 is a clinical study titled "Salmonella Conjugates CVD 1000: Study of Responses to Vaccination With Trivalent Invasive Salmonella Disease Vaccine". This is a randomized, placebo-controlled dose-escalation study. The main purpose of this research is to test the safety and measure the immune response of the trivalent vaccine against invasive Salmonella disease. The vaccine will be tested over a range of doses.
What is the current status of trial NCT03981952?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 96 participants. The study started on 2019-10-28. Estimated completion is 2021-05-07.
What conditions does trial NCT03981952 study?
This clinical trial studies the following conditions: Risk Reduction. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03981952?
The interventions under investigation include: Placebo (OTHER), Trivalent Invasive Salmonella Disease Vaccine (6.25 µg) (BIOLOGICAL), Trivalent Invasive Salmonella Disease Vaccine (12 µg) (BIOLOGICAL), Trivalent Invasive Salmonella Disease Vaccine (25 µg) (BIOLOGICAL), Trivalent Invasive Salmonella Disease Vaccine (highest, well-tolerated dose among Cohorts A-C) (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03981952?
This trial is sponsored by University of Maryland, Baltimore, which has 559 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03981952 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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