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NCT03954938 · ClinicalTrials.gov registry record · Early Phase 1
Behavioral Effects of Drugs (Inpatient): 38
A Early Phase 1 study, sponsored by William Stoops.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 5
- Enrollment target
NCT03954938 is a Early Phase 1 study that was terminated before completion, run by William Stoops. The registered enrollment target is 5 participants.
The verdict
NCT03954938, a Early Phase 1 study, was terminated before completion, sponsored by William Stoops.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
The specific aim of this project is to demonstrate that the decisional analysis/craving regulation aspects of CBT reduce cocaine self-administration in subjects with cocaine use disorder through diminished craving responses. Thirty non-treatment seeking human subjects meeting diagnostic criteria for cocaine use disorder will complete an outpatient, crossover, placebo-controlled study consisting of 1 practice and 9 experimental sessions. In each experimental session, the reinforcing effects of intranasal cocaine will be determined under one of three regulation of craving conditions that simulate CBT decisional analysis (i.e., negative instruction, positive instruction or a neutral "look" condition). After sampling the dose of cocaine available in each session, subjects will complete the craving manipulation assigned to that session, they will then rate their craving and finally they will have the opportunity to earn the sampled dose in a progressive-ratio procedure. We hypothesize that focusing on the negative effects of cocaine use will decrease craving and reduce cocaine self-administration relative to the positive and "look" conditions, and that craving will be positively correlated with self-administration outcomes.
Interventions
- DRUG Placebo
- DRUG Cocaine
- BEHAVIORAL Craving Manipulation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2019-05-15 |
| Est. Completion | 2021-12-03 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03954938
The ClinicalTrials.gov registry entry for NCT03954938 describes a study currently listed as terminated, categorized as Early Phase 1. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is William Stoops, which has 13 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT03954938 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03954938 about?
NCT03954938 is a clinical study titled "Behavioral Effects of Drugs (Inpatient): 38". The specific aim of this project is to demonstrate that the decisional analysis/craving regulation aspects of CBT reduce cocaine self-administration in subjects with cocaine use disorder through diminished craving responses. Thirty non-treatment seeking human subjects meeting diagnostic criteria for...
What is the current status of trial NCT03954938?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 5 participants. The study started on 2019-05-15. Estimated completion is 2021-12-03.
What interventions are being tested in trial NCT03954938?
The interventions under investigation include: Placebo (DRUG), Cocaine (DRUG), Craving Manipulation (BEHAVIORAL).
Who is sponsoring clinical trial NCT03954938?
This trial is sponsored by William Stoops, which has 13 total clinical trials registered on ClinicalTrials.gov.
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