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NCT03932643 · ClinicalTrials.gov registry record · Phase 1
ONC-201 Maintenance Therapy in Acute Myeloid Leukemia and Myelodysplastic Syndrome After Stem Cell Transplant
A Phase 1 study, sponsored by University of Nebraska.
- Completed
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
NCT03932643: Completed Phase 1 study, sponsored by University of Nebraska.
NCT03932643 is a Phase 1 study that has completed, run by University of Nebraska. The registered enrollment target is 20 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03932643, a Phase 1 study, has completed, sponsored by University of Nebraska.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
Study Summary
This is a single-center Phase 1 trial of 20 patients with AML/MDS. Eligible patients will be enrolled following an informed consent between 6-20 weeks after allogeneic hematopoietic stem cell transplant. Patients will receive weekly oral ONC 201 for a total of 52 weeks.
Primary Outcome
The rate of dose limiting toxicities during the first cycle (among the dose escalating cohort)
Interventions
- DRUG ONC-201
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2019-07-30 |
| Est. Completion | 2025-03-27 |
| Phase | Phase 1 |
What the finished NCT03932643 record still lists
NCT03932643 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (67% lower).
The record links to 0 conditions, and to 1 intervention - of which ONC-201 is the first listed.
NCT03932643 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03932643 about?
NCT03932643 is a clinical study titled "ONC-201 Maintenance Therapy in Acute Myeloid Leukemia and Myelodysplastic Syndrome After Stem Cell Transplant". This is a single-center Phase 1 trial of 20 patients with AML/MDS. Eligible patients will be enrolled following an informed consent between 6-20 weeks after allogeneic hematopoietic stem cell transplant. Patients will receive weekly oral ONC 201 for a total of 52 weeks.
What is the current status of trial NCT03932643?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2019-07-30. Estimated completion is 2025-03-27.
What interventions are being tested in trial NCT03932643?
The interventions under investigation include: ONC-201 (DRUG).
Who is sponsoring clinical trial NCT03932643?
This trial is sponsored by University of Nebraska, which has 407 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03932643's enrollment target sits among peer trials
20 1629th of 2000 higher than 285 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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