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NCT03929302 · ClinicalTrials.gov registry record · NA
Brain Energy Metabolism and Sleep in Adults
A NA study, sponsored by The University of Texas at Dallas.
- Terminated
- Registry status
- NA
- Development phase
- 41
- Enrollment target
NCT03929302: Clinical Trial NA study, sponsored by The University of Texas at Dallas.
NCT03929302 is a NA study that was terminated before completion, run by The University of Texas at Dallas. The registered enrollment target is 41 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03929302, a NA study, was terminated before completion, sponsored by The University of Texas at Dallas.
- TERMINATED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
Study Summary
The three primary goals of this pilot will be followed by a secondary goal to test if dental intervention improves brain health in terms of sleep and cognition. The primary and secondary goals are 1. Explore the ratios of brain energy (ATP/PCr, Pi/PCr) and phospholipids (PME/PDE) metabolites as measured by magnetic resonance spectroscopy at 7 Tesla, and compare the differences in them with the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in three groups: cognitively normal adults, mild cognitive impairment (MCI) and Alzheimer's disease (AD). 2. Investigate the differences in sleep patterns measured by the ratio sleep quality index (Stable/ Unstable sleep) in cognitively normal adults, MCI and AD and its relation to the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in three groups. 3. Investigate the differences in the variations of two genes, APOE-E4 and ABCA7, in relationship to the changes in the brain energy metabolites and its relation to the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in those with cognitively normal adults, MCI and AD. 4. Investigate if dental intervention improves sleep patterns and overall cognitive behavior in the three cohorts.
Primary Outcome
To investigate the short-term effects of dental intervention on cognition, especially the memory domain of Montreal Cognitive assessment. The score ranges between 0 and 30. A score between 26 to 30 is considered to be normal. A score between 20 and 25 is for mild cognitive impairment. A score less than 20 is for Alzheimer's disease.
Interventions
- DEVICE MyTAP oral appliance plus mouth shield
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2018-11-30 |
| Est. Completion | 2020-01-31 |
| Phase | NA |
Why NCT03929302 stopped before completion
NCT03929302 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 41 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which MyTAP oral appliance plus mouth shield is the first listed.
NCT03929302 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03929302 about?
NCT03929302 is a clinical study titled "Brain Energy Metabolism and Sleep in Adults". The three primary goals of this pilot will be followed by a secondary goal to test if dental intervention improves brain health in terms of sleep and cognition. The primary and secondary goals are 1. Explore the ratios of brain energy (ATP/PCr, Pi/PCr) and phospholipids (PME/PDE) metabolites as mea...
What is the current status of trial NCT03929302?
This trial is currently terminated. It is a NA study. The enrollment target is 41 participants. The study started on 2018-11-30. Estimated completion is 2020-01-31.
What interventions are being tested in trial NCT03929302?
The interventions under investigation include: MyTAP oral appliance plus mouth shield (DEVICE).
Who is sponsoring clinical trial NCT03929302?
This trial is sponsored by The University of Texas at Dallas, which has 50 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03929302's enrollment target sits among peer trials
41 1446th of 2000 higher than 554 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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