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NCT03929302 · ClinicalTrials.gov registry record · NA
Brain Energy Metabolism and Sleep in Adults
A NA study, sponsored by The University of Texas at Dallas.
- Terminated
- Registry status
- NA
- Development phase
- 41
- Enrollment target
NCT03929302 is a NA study that was terminated before completion, run by The University of Texas at Dallas. The registered enrollment target is 41 participants.
The verdict
NCT03929302, a NA study, was terminated before completion, sponsored by The University of Texas at Dallas.
- TERMINATED
- Registry status
- NA
- Development phase
- 41 participants
- Enrollment target
Study Summary
The three primary goals of this pilot will be followed by a secondary goal to test if dental intervention improves brain health in terms of sleep and cognition. The primary and secondary goals are 1. Explore the ratios of brain energy (ATP/PCr, Pi/PCr) and phospholipids (PME/PDE) metabolites as measured by magnetic resonance spectroscopy at 7 Tesla, and compare the differences in them with the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in three groups: cognitively normal adults, mild cognitive impairment (MCI) and Alzheimer's disease (AD). 2. Investigate the differences in sleep patterns measured by the ratio sleep quality index (Stable/ Unstable sleep) in cognitively normal adults, MCI and AD and its relation to the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in three groups. 3. Investigate the differences in the variations of two genes, APOE-E4 and ABCA7, in relationship to the changes in the brain energy metabolites and its relation to the performance of episodic memory, attention, language, and executive functions (abstraction, reasoning, verbal fluency, working memory) in those with cognitively normal adults, MCI and AD. 4. Investigate if dental intervention improves sleep patterns and overall cognitive behavior in the three cohorts.
Interventions
- DEVICE MyTAP oral appliance plus mouth shield
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2018-11-30 |
| Est. Completion | 2020-01-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03929302
The ClinicalTrials.gov registry entry for NCT03929302 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is The University of Texas at Dallas, which has 50 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which MyTAP oral appliance plus mouth shield is the first listed.
NCT03929302 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03929302 about?
NCT03929302 is a clinical study titled "Brain Energy Metabolism and Sleep in Adults". The three primary goals of this pilot will be followed by a secondary goal to test if dental intervention improves brain health in terms of sleep and cognition. The primary and secondary goals are 1. Explore the ratios of brain energy (ATP/PCr, Pi/PCr) and phospholipids (PME/PDE) metabolites as mea...
What is the current status of trial NCT03929302?
This trial is currently terminated. It is a NA study. The enrollment target is 41 participants. The study started on 2018-11-30. Estimated completion is 2020-01-31.
What interventions are being tested in trial NCT03929302?
The interventions under investigation include: MyTAP oral appliance plus mouth shield (DEVICE).
Who is sponsoring clinical trial NCT03929302?
This trial is sponsored by The University of Texas at Dallas, which has 50 total clinical trials registered on ClinicalTrials.gov.
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