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NCT03876314 · ClinicalTrials.gov registry record · NA
Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype
A NA study, sponsored by University of North Carolina, Greensboro.
- Completed
- Registry status
- NA
- Development phase
- 180
- Enrollment target
NCT03876314: Completed NA study, sponsored by University of North Carolina, Greensboro.
NCT03876314 is a NA study that has completed, run by University of North Carolina, Greensboro. The registered enrollment target is 180 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03876314, a NA study, has completed, sponsored by University of North Carolina, Greensboro.
- COMPLETED
- Registry status
- NA
- Development phase
- 180 participants
- Enrollment target
Study Summary
Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the extent to which this effect is moderated by apolipoprotein epsilon-4 (APOE4) carrier status, and will gather critical new experimental evidence on the use of physical activity to improve cognitive performance by persons at the greatest risk of Alzheimer's disease.
Primary Outcome
Change in executive function will be assessed by comparing Pre-Test, Mid-Test (\~6 months), and Post-Test (\~12 months) performance on Stroop Interference. Stroop interference is calculated using reaction time (RT) data from correct trials and the following formula: Stroop Interference RT = Stroop Incongruent RT - (average (Stroop Congruent RT , Stroop Neutral RT)). Stroop Congruent is also known as Stroop Word, and Stroop Neutral is also known as Stroop Color. RT is recorded in msec and a large
Interventions
- BEHAVIORAL Physical Activity Condition
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2019-05-23 |
| Est. Completion | 2024-12-21 |
| Phase | NA |
What the finished NCT03876314 record still lists
NCT03876314 is an interventional study that assigns participants to a tested intervention. The registered 180 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 1 intervention - of which Physical Activity Condition is the first listed.
NCT03876314 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03876314 about?
NCT03876314 is a clinical study titled "Physical Activity, Alzheimer's Disease and Cognition Relative to APOE Genotype". Physical activity and Alzheimer's disease (PAAD-2) is a randomized control trial that will assess the effects of exercise on middle-aged (40-65 years) cognitively normal adults who have a heightened risk of Alzheimer's disease (AD) due to family history (FH+). The investigators will also assess the ...
What is the current status of trial NCT03876314?
This trial is currently completed. It is a NA study. The enrollment target is 180 participants. The study started on 2019-05-23. Estimated completion is 2024-12-21.
What interventions are being tested in trial NCT03876314?
The interventions under investigation include: Physical Activity Condition (BEHAVIORAL).
Who is sponsoring clinical trial NCT03876314?
This trial is sponsored by University of North Carolina, Greensboro, which has 15 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03876314's enrollment target sits among peer trials
180 586th of 2000 higher than 1,397 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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