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NCT03876002 · ClinicalTrials.gov registry record · Phase 1
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET
A Phase 1 study, sponsored by Molecular NeuroImaging.
- Completed
- Registry status
- Phase 1
- Development phase
- 23
- Enrollment target
NCT03876002: Completed Phase 1 study, sponsored by Molecular NeuroImaging.
NCT03876002 is a Phase 1 study that has completed, run by Molecular NeuroImaging. The registered enrollment target is 23 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03876002, a Phase 1 study, has completed, sponsored by Molecular NeuroImaging.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 23 participants
- Enrollment target
Study Summary
The overall goal of this protocol is to evaluate microglial activation in the brain using \[18F\]PBR06 in patients with amyotrophic lateral sclerosis (ALS).
Primary Outcome
Time-activity data will be analyzed with 2-tissue compartment model, using the radiometabolite-corrected plasma input function. To correct the brain data for its vascular component, radioactivity in serial whole blood will be measured and then subtracted from the PET measurements. Non-invasive simple tissue ratio methods will also be evaluated.
Interventions
- DRUG [18F]PBR06
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2016-06-28 |
| Est. Completion | 2018-02-07 |
| Phase | Phase 1 |
What the finished NCT03876002 record still lists
NCT03876002 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (62% lower).
The record links to 0 conditions, and to 1 intervention - of which [18F]PBR06 is the first listed.
NCT03876002 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03876002 about?
NCT03876002 is a clinical study titled "Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET". The overall goal of this protocol is to evaluate microglial activation in the brain using \[18F\]PBR06 in patients with amyotrophic lateral sclerosis (ALS).
What is the current status of trial NCT03876002?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 23 participants. The study started on 2016-06-28. Estimated completion is 2018-02-07.
What interventions are being tested in trial NCT03876002?
The interventions under investigation include: [18F]PBR06 (DRUG).
Who is sponsoring clinical trial NCT03876002?
This trial is sponsored by Molecular NeuroImaging, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03876002's enrollment target sits among peer trials
23 1596th of 2000 higher than 400 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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