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Cold Snare Endoscopic Mucosal Resection Trial
NCT03865537 · View on ClinicalTrials.gov ↗
Study Summary
This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design. The first randomization will assign half of patients to polyp resection with electrocautery ("hot" snare EMR) and half of patient to polyp resection without electrocautery ("cold" snare EMR). The second randomization will assign half of patients to polyp removal using Eleview as the submucosal injection agent, and the other half using placebo (normal saline with methylene blue) as the submucosal injection agent.
Conditions Studied
Interventions
- PROCEDURE Cold snare EMR
- PROCEDURE Hot snare EMR
- PROCEDURE Eleview injection
- PROCEDURE Placebo injection
Study Locations (1)
Vermont
- White River Junction VAMC — White River Junction
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 990 participants |
| Start Date | 2019-10-01 |
| Est. Completion | 2027-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03865537
The ClinicalTrials.gov registry entry for NCT03865537 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 990 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is White River Junction Veterans Affairs Medical Center, which has 32 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Colonoscopy appearing as the primary indexed condition, and to 4 interventions — of which Cold snare EMR is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03865537 reports 1 study location spanning 1 distinct geographic area — top geographies include Vermont. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03865537 about?
NCT03865537 is a clinical study titled "Cold Snare Endoscopic Mucosal Resection Trial". This study compares different approaches to endoscopic mucosal resection (EMR) of large non-pedunculated colorectal polyps (≥20mm) in a 2 x 2 randomized design. The first randomization will assign half of patients to polyp resection with electrocautery ("hot" snare EMR) and half of patient to polyp ...
What is the current status of trial NCT03865537?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 990 participants. The study started on 2019-10-01. Estimated completion is 2027-01.
What conditions does trial NCT03865537 study?
This clinical trial studies the following conditions: Colonoscopy, Recurrence, Complication, Colonic Polyp. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03865537?
The interventions under investigation include: Cold snare EMR (PROCEDURE), Hot snare EMR (PROCEDURE), Eleview injection (PROCEDURE), Placebo injection (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03865537?
This trial is sponsored by White River Junction Veterans Affairs Medical Center, which has 32 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03865537 being conducted?
This trial has 1 study location across Vermont. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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