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NCT03865420 · ClinicalTrials.gov registry record
Amyotrophic Lateral Sclerosis (ALS) Families Project
A clinical trial of ALS, sponsored by Columbia University.
- Recruiting
- Registry status
- 300
- Enrollment target
- 1
- Study location
NCT03865420: Recruiting study of ALS, sponsored by Columbia University.
NCT03865420 is a study of ALS that is actively recruiting participants, run by Columbia University. The registered enrollment target is 300 participants, below the 1,021-participant average among 19 other ALS trials with a reported enrollment target (71% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03865420, a study of ALS, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- 300 participants
- Enrollment target
- 1
- Study location
Study Summary
This program provides family members of individuals with familial ALS the opportunity to contribute to research focused on learning more about why motor neuron degeneration begins and how or why it progresses. This study provides genetic counseling and testing to help participants understand and manage their risk and determine if they want to learn their genetic status. This study will follow unaffected ALS gene mutation carriers on an annual basis to gather essential information that will ultimately help researchers develop novel therapies for the prevention and treatment of ALS.
Primary Outcome
Emergence of symptoms will defined by the development of any of the following: a) any weakness on neurological examination, b) evidence of nerve loss on electromyography (EMG)-nerve conduction studies, or c) evidence of cognitive impairment on the ECAS or ALS-Cognitive Behavioral Scale (ALS-CBS).
Conditions Studied
Study Locations (1)
New York
- Columbia University - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2018-09-11 |
| Est. Completion | 2027-01 |
What NCT03865420 shows while recruiting
NCT03865420 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap, below the 1,021-participant average among 19 other ALS trials with a reported enrollment target (71% lower).
The record links to 1 condition, with ALS appearing as the primary indexed condition, and to 0 interventions.
NCT03865420 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT03865420 about?
NCT03865420 is a clinical study titled "Amyotrophic Lateral Sclerosis (ALS) Families Project". This program provides family members of individuals with familial ALS the opportunity to contribute to research focused on learning more about why motor neuron degeneration begins and how or why it progresses. This study provides genetic counseling and testing to help participants understand and man...
What is the current status of trial NCT03865420?
This trial is currently recruiting. The enrollment target is 300 participants. The study started on 2018-09-11. Estimated completion is 2027-01.
What conditions does trial NCT03865420 study?
This clinical trial studies the following conditions: ALS.
Who is sponsoring clinical trial NCT03865420?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03865420 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for ALS
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03865420's enrollment target sits among peer trials
300 6th of 19 higher than 14 of 19 other ALS trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other ALS trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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