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NCT03848715 · ClinicalTrials.gov registry record · Phase 1
Sleep and Healthy Aging Research on Depression for Younger Women
A Phase 1 study, sponsored by University of California, Los Angeles.
- Completed
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
NCT03848715: Completed Phase 1 study, sponsored by University of California, Los Angeles.
NCT03848715 is a Phase 1 study that has completed, run by University of California, Los Angeles. The registered enrollment target is 40 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03848715, a Phase 1 study, has completed, sponsored by University of California, Los Angeles.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
Study Summary
Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipating versus receiving a reward) and types (e.g., money vs. smiling faces) in younger and older women. Characterizing how inflammation shapes the dynamic and multidimensional reward system, and how this may differ by age, may give insight into risk factors for depression and help identify critical points for intervention.
Primary Outcome
Implicit reward learning and sensitivity to monetary reward is assessed with the probabilistic reward task (PRT) a behavioral computer task; change in the magnitude of response bias from baseline to post-injection is the outcome measure. More positive response bias indicates a bias towards the more frequently reward stimuli (a better outcome); more negative response bias indicates a bias towards the less frequently reward stimuli (a worse outcome). This is not a standardized scale with minimum a
Interventions
- BIOLOGICAL Placebo
- BIOLOGICAL Endotoxin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2019-10-02 |
| Est. Completion | 2024-07-22 |
| Phase | Phase 1 |
What the finished NCT03848715 record still lists
NCT03848715 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (33% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT03848715 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03848715 about?
NCT03848715 is a clinical study titled "Sleep and Healthy Aging Research on Depression for Younger Women". Compelling evidence indicates inflammation plays a role in depression, but potential mechanisms linking inflammation to depression, such as dysregulated reward processing, are poorly understood. This study comprehensively evaluates effects of inflammation on reward across dimensions (e.g., anticipat...
What is the current status of trial NCT03848715?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2019-10-02. Estimated completion is 2024-07-22.
What interventions are being tested in trial NCT03848715?
The interventions under investigation include: Placebo (BIOLOGICAL), Endotoxin (BIOLOGICAL).
Who is sponsoring clinical trial NCT03848715?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03848715's enrollment target sits among peer trials
40 1130th of 2000 higher than 810 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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