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NCT03848325 · ClinicalTrials.gov registry record · NA
Poor Sleep and Inflammation in HIV-Infected Adults
A NA study, sponsored by University of Pittsburgh.
- Completed
- Registry status
- NA
- Development phase
- 20
- Enrollment target
NCT03848325 is a NA study that has completed, run by University of Pittsburgh. The registered enrollment target is 20 participants.
The verdict
NCT03848325, a NA study, has completed, sponsored by University of Pittsburgh.
- COMPLETED
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
Study Summary
People living with HIV (PLWH) often have poor sleep, which may put them at a higher risk for many chronic diseases, including cardiovascular disease. One of the mechanisms by which this may occur is via chronic inflammation and endothelial dysfunction. Adenosine plays an important role in sleep homeostasis, with levels increasing in the CSF in response to sleep deprivation and falling with sleep. Peripherally, adenosine, via its signaling pathway, plays an important role in immunoregulation by suppressing the inflammatory response. PLWH, even on antiretroviral therapy, have suppressed peripheral adenosine levels which are predictive of adverse cardiovascular outcomes. The hypothesis underlying this study is that acute sleep deprivation in PLWH does not result in a compensatory increase in extracellular adenosine and its signaling peripherally, and this failure to appropriately compensate, leads to an increase in systemic inflammation and endothelial dysfunction.
Interventions
- BEHAVIORAL Sleep deprivation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2020-11-09 |
| Est. Completion | 2022-07-31 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03848325
The ClinicalTrials.gov registry entry for NCT03848325 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Pittsburgh, which has 1,238 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Sleep deprivation is the first listed.
NCT03848325 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03848325 about?
NCT03848325 is a clinical study titled "Poor Sleep and Inflammation in HIV-Infected Adults". People living with HIV (PLWH) often have poor sleep, which may put them at a higher risk for many chronic diseases, including cardiovascular disease. One of the mechanisms by which this may occur is via chronic inflammation and endothelial dysfunction. Adenosine plays an important role in sleep home...
What is the current status of trial NCT03848325?
This trial is currently completed. It is a NA study. The enrollment target is 20 participants. The study started on 2020-11-09. Estimated completion is 2022-07-31.
What interventions are being tested in trial NCT03848325?
The interventions under investigation include: Sleep deprivation (BEHAVIORAL).
Who is sponsoring clinical trial NCT03848325?
This trial is sponsored by University of Pittsburgh, which has 1,238 total clinical trials registered on ClinicalTrials.gov.
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