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Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa
NCT03827798 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to assess preliminary efficacy and safety of CFZ533/iscalimab (Cohort A), LYS006 (Cohort B), MAS825 (Cohort C), LOU064/remibrutinib (Cohort D) and VAY736/ianalumab (Cohort E) in patients with moderate to severe hidradenitis suppurativa and to determine if CFZ533, LYS006, MAS825, LOU064 and VAY736 have an adequate clinical profile for further clinical development.
Conditions Studied
Interventions
- DRUG MAS825
- DRUG CFZ533
- DRUG Placebo to CFZ533
- DRUG LYS006
- DRUG Placebo to LYS006
Study Locations (20)
Other
- Novartis Investigative Site — Graz
- Novartis Investigative Site — Brussels
- Novartis Investigative Site — Copenhagen
- Novartis Investigative Site — Roskilde
- Novartis Investigative Site — Antony
- Novartis Investigative Site — Lyon
- Novartis Investigative Site — Marseille
- Novartis Investigative Site — Nice
- Novartis Investigative Site — Reims
- Novartis Investigative Site — Rouen
- Novartis Investigative Site — Bochum
Florida
- Olympian Clinical Research — Clearwater
- Park Avenue Dermatology PA — Orange Park
- University Of South Florida — Tampa
Georgia
- Advanced Medical Research — Sandy Springs
Illinois
- NorthShore University Health System — Evanston
Indiana
- Dawes Fretzin Clinical Rea Group — Indianapolis
Pennsylvania
- Penn State Milton S Hershey Medical Center — Hershey
South Carolina
- Medical University of South Carolina MUSC — Charleston
Prague 1
- Novartis Investigative Site — Prague
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 248 participants |
| Start Date | 2019-02-27 |
| Est. Completion | 2026-12-11 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03827798
The ClinicalTrials.gov registry entry for NCT03827798 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 248 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novartis Pharmaceuticals, which has 792 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hidradenitis Suppurativa appearing as the primary indexed condition, and to 5 interventions — of which MAS825 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03827798 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Other, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03827798 about?
NCT03827798 is a clinical study titled "Study of Efficacy and Safety of Investigational Treatments in Patients With Moderate to Severe Hidradenitis Suppurativa". The main purpose of this study is to assess preliminary efficacy and safety of CFZ533/iscalimab (Cohort A), LYS006 (Cohort B), MAS825 (Cohort C), LOU064/remibrutinib (Cohort D) and VAY736/ianalumab (Cohort E) in patients with moderate to severe hidradenitis suppurativa and to determine if CFZ533, LY...
What is the current status of trial NCT03827798?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 248 participants. The study started on 2019-02-27. Estimated completion is 2026-12-11.
What conditions does trial NCT03827798 study?
This clinical trial studies the following conditions: Hidradenitis Suppurativa. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03827798?
The interventions under investigation include: MAS825 (DRUG), CFZ533 (DRUG), Placebo to CFZ533 (DRUG), LYS006 (DRUG), Placebo to LYS006 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03827798?
This trial is sponsored by Novartis Pharmaceuticals, which has 792 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03827798 being conducted?
This trial has 20 study locations across Florida, Georgia, Illinois, Indiana, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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