Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03806023 · ClinicalTrials.gov registry record · NA
EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals
A NA study, sponsored by Bronx VA Medical Center.
- Terminated
- Registry status
- NA
- Development phase
- 8
- Enrollment target
NCT03806023 is a NA study that was terminated before completion, run by Bronx VA Medical Center. The registered enrollment target is 8 participants.
The verdict
NCT03806023, a NA study, was terminated before completion, sponsored by Bronx VA Medical Center.
- TERMINATED
- Registry status
- NA
- Development phase
- 8 participants
- Enrollment target
Study Summary
Most individuals with spinal cord injury (SCI) have residual nerve circuits. The investigators aim to strengthen those circuits to improve motor recovery after injury. To do this, the investigators are attempting to pair electrical and magnetic stimulation with physical training targeted toward the connections between nerve circuits. Past studies by other groups have shown that synapse strength can be improved temporarily after a short period of paired stimulation between the brain (motor cortex) and the peripheral nerves serving target muscles - in other words, "Fire Together, Wire Together". The brain's intention to move a muscle can be read by recording surface electrical activity over target muscles (electromyography or EMG). In animal models of SCI, scientists have successfully used target muscle EMG to trigger spinal cord electrical stimulation pulses while the animals perform physical exercises. Using the body's own signals to trigger nerve stimulation is called "closed-loop stimulation". This might be an optimal method to coordinate brain and nerve activity, especially with the clinical advantage of being possible to combine with physical exercise training. However, whether EMG-triggered closed loop stimulation has the same amount of effect when applied non-invasively in humans is still unknown. This proposed study is a proof-of-principle to demonstrate the potential of non-invasive closed-loop stimulation in humans with incomplete cervical SCI. We will test different combinations of triggered and non-triggered electrical and magnetic stimulation, and record the short-term effects on nerve transmission and skilled function of hand muscles. This pilot study will be a foundation for future studies combining EMG-triggered stimulation with long-term physical exercise training.
Interventions
- DEVICE hand movements (signals from thumb muscle) triggered PNS and TMS
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2018-02-01 |
| Est. Completion | 2020-02-28 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03806023
The ClinicalTrials.gov registry entry for NCT03806023 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 8 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Bronx VA Medical Center, which has 13 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which hand movements (signals from thumb muscle) triggered PNS and TMS is the first listed.
NCT03806023 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03806023 about?
NCT03806023 is a clinical study titled "EMG Triggered Closed-Loop Stimulation for Spinal Cord Injury Individuals". Most individuals with spinal cord injury (SCI) have residual nerve circuits. The investigators aim to strengthen those circuits to improve motor recovery after injury. To do this, the investigators are attempting to pair electrical and magnetic stimulation with physical training targeted toward the ...
What is the current status of trial NCT03806023?
This trial is currently terminated. It is a NA study. The enrollment target is 8 participants. The study started on 2018-02-01. Estimated completion is 2020-02-28.
What interventions are being tested in trial NCT03806023?
The interventions under investigation include: hand movements (signals from thumb muscle) triggered PNS and TMS (DEVICE).
Who is sponsoring clinical trial NCT03806023?
This trial is sponsored by Bronx VA Medical Center, which has 13 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.