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NCT03780829 · ClinicalTrials.gov registry record · Early Phase 1
AIH for Spinal Cord Repair
A Early Phase 1 study, sponsored by VA Office of Research and Development.
- Terminated
- Registry status
- Early Phase 1
- Development phase
- 50
- Enrollment target
NCT03780829: Clinical Trial Early Phase 1 study, sponsored by VA Office of Research and Development.
NCT03780829 is a Early Phase 1 study that was terminated before completion, run by VA Office of Research and Development. The registered enrollment target is 50 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03780829, a Early Phase 1 study, was terminated before completion, sponsored by VA Office of Research and Development.
- TERMINATED
- Registry status
- Early Phase 1
- Development phase
- 50 participants
- Enrollment target
Study Summary
Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life. Promoting neuroplasticity may support upper limb recovery after SCI. Repetitive exposure to acute intermittent hypoxia (rAIH) combined with motor training promotes recovery of motor function after SCI; however, the overall effects of rAIH/training are limited. The investigators will use an adult rat model of long-term contusive cSCI to study novel approaches to enhance the effect of rAIH/training on forelimb function and study the neuronal substrate underlying the effects. The findings will be used to direct the development of more effective rAIH/training approaches for people with contusive, functionally incomplete, cSCI. Because deficits in upper limb function are a major problem after stroke, amyotrophic lateral sclerosis, multiple sclerosis, and other motor disorders, this work may also be relevant for patients with other types of central nervous system (CNS) lesions.
Interventions
- DRUG D-cycloserine
- BEHAVIORAL exercise training
- BEHAVIORAL hypoxia
- BEHAVIORAL sham hypoxia
- DRUG sham-NMDA agonist
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2020-02-25 |
| Est. Completion | 2026-02-05 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03780829
The ClinicalTrials.gov registry entry for NCT03780829 describes a study currently listed as terminated, categorized as Early Phase 1. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is VA Office of Research and Development, which has 1,668 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which D-cycloserine is the first listed.
NCT03780829 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03780829 about?
NCT03780829 is a clinical study titled "AIH for Spinal Cord Repair". Contusive cervical spinal cord injury (cSCI) impairs upper limb function (reach-and-grasp) which limits daily-life activities and thus decreases the quality of life. Promoting neuroplasticity may support upper limb recovery after SCI. Repetitive exposure to acute intermittent hypoxia (rAIH) combined...
What is the current status of trial NCT03780829?
This trial is currently terminated. It is a Early Phase 1 study. The enrollment target is 50 participants. The study started on 2020-02-25. Estimated completion is 2026-02-05.
What interventions are being tested in trial NCT03780829?
The interventions under investigation include: D-cycloserine (DRUG), exercise training (BEHAVIORAL), hypoxia (BEHAVIORAL), sham hypoxia (BEHAVIORAL), sham-NMDA agonist (DRUG).
Who is sponsoring clinical trial NCT03780829?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
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