Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03769155 · ClinicalTrials.gov registry record · Phase 1
VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma
A Phase 1 study of Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 and Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, sponsored by Emory University.
- Active
- Registry status
- Phase 1
- Development phase
- 41
- Enrollment target
- 1
- Study location
NCT03769155 is a Phase 1 study of Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 and Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 that is active but no longer recruiting, run by Emory University. The registered enrollment target is 41 participants, below the 69-participant average among 6 other Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 trials with a reported enrollment target (41% lower). The trial reports 1 study location across 1 state.
The verdict
NCT03769155, a Phase 1 study of Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 and Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, is active but no longer recruiting, sponsored by Emory University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 41 participants
- Enrollment target
- 1
- Study location
Study Summary
This pilot phase I trial studies how well VX15/2503 (pepinemab) with or without ipilimumab and/or nivolumab work in treating participants with stage IIIB-D melanoma that can be removed by surgery. Monoclonal antibodies, such as VX15/2503, ipilimumab, and nivolumab may interfere with the ability of tumor cells to grow and spread.
Conditions Studied
Interventions
- BIOLOGICAL Nivolumab
- PROCEDURE Surgery
- BIOLOGICAL Ipilimumab
- BIOLOGICAL VX15/2503
Study Locations (1)
Georgia
- Emory University Hospital/Winship Cancer Institute - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 41 participants |
| Start Date | 2018-12-13 |
| Est. Completion | 2032-12-15 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03769155
The ClinicalTrials.gov registry entry for NCT03769155 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 41 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 69-participant average among 6 other Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 trials with a reported enrollment target (41% lower). The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 appearing as the primary indexed condition, and to 4 interventions - of which Nivolumab is the first listed.
NCT03769155 reports 1 study location spanning 1 distinct geographic area - top geographies include Georgia.
Frequently Asked Questions
What is clinical trial NCT03769155 about?
NCT03769155 is a clinical study titled "VX15/2503 With or Without Ipilimumab and/or Nivolumab in Patients With Resectable Stage IIIB-D Melanoma". This pilot phase I trial studies how well VX15/2503 (pepinemab) with or without ipilimumab and/or nivolumab work in treating participants with stage IIIB-D melanoma that can be removed by surgery. Monoclonal antibodies, such as VX15/2503, ipilimumab, and nivolumab may interfere with the ability of t...
What is the current status of trial NCT03769155?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 41 participants. The study started on 2018-12-13. Estimated completion is 2032-12-15.
What conditions does trial NCT03769155 study?
This clinical trial studies the following conditions: Pathologic Stage IIIC Cutaneous Melanoma AJCC v8, Pathologic Stage IIIB Cutaneous Melanoma AJCC v8, Pathologic Stage IIID Cutaneous Melanoma AJCC v8.
What interventions are being tested in trial NCT03769155?
The interventions under investigation include: Nivolumab (BIOLOGICAL), Surgery (PROCEDURE), Ipilimumab (BIOLOGICAL), VX15/2503 (BIOLOGICAL).
Who is sponsoring clinical trial NCT03769155?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03769155 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
RECRUITING · Phase 1
-
Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients
ACTIVE NOT RECRUITING · Phase 1
-
Immune Related Toxicity and Symptom Burden in Chronic Cancer Survivors With Melanoma Receiving Adjuvant Immunotherapy With Immune Checkpoint Inhibitors
ACTIVE NOT RECRUITING
-
A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy of Treatment in Patients With Operable Melanoma
ACTIVE NOT RECRUITING · Phase 2
-
Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial
ACTIVE NOT RECRUITING · Phase 2
-
Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma
ACTIVE NOT RECRUITING · Phase 2
Explore more on PlainTrial
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
All registered trials for this condition
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
All registered trials for this condition
Georgia
All trials with a study site in Georgia
Recruiting now
Find trials open to new participants near you
Rankings
Top sponsors, conditions, and phases
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.