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NCT03768999 · ClinicalTrials.gov registry record
Comparison of Magnetic Resonance Coronary Angiography (MRCA) With Coronary Computed Tomography Angiography (CTA)
A clinical trial, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- 16
- Enrollment target
NCT03768999: Clinical Trial study, sponsored by Johns Hopkins University.
NCT03768999 is a clinical trial that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 16 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03768999 was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- 16 participants
- Enrollment target
Study Summary
Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. The clinical application of MRCA is still challenging mainly because of technical limitations such as: its time-consuming image acquisition, inconsistent image quality, and low spatial resolution. Optimization of MRCA image acquisition method is in progress and compressed sensing (CS) with post-processing (de-noising) by deep learning reconstruction (DLR) is promising to solve these problems. The lack of a consensus method to assess the coronary stenosis on MRCA is another issue. Generally, a stenosis in MRCA is observed as a signal intensity (SI) drop along the artery compared to the healthy segments. A previous study has reported from its comparison of MRCA with coronary angiography (CAG) that the SI drop of 35% in MRCA stenosis lesion corresponded to the significant stenosis in CAG. Although this SI drop phenomenon was not observed in a different study on chronic total obstruction cases. One of the hypothesized reasons is that the SI drop in MRCA is affected not only by the stenosis severity but also the plaque characteristics, which is not assessable by CAG. To investigate this hypothesis coronary CTA is needed, which is a robust modality to assess coronary stenosis and plaque characteristics. Comparison between MRCA with CTA has the potential to give better information for developing a robust method to assess MRCA. In this study, the investigators aim to evaluate the feasibility of MRCA scanned with optimized protocol and post-processing, and to develop robust coronary artery assessment method on MRCA, by comparison with clinical coronary CTA.
Primary Outcome
MRCA signal intensity change compared to the proximal or distal segments of the coronary artery will be measured and compared with corresponding lesion of coronary CTA. The threshold of SI drop (%) which corresponds to the significant stenosis in CTA will be assessed.
Interventions
- DIAGNOSTIC_TEST Non-contrast magnetic resonance coronary angiography (MRCA)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2019-09-03 |
| Est. Completion | 2025-07-31 |
Why NCT03768999 stopped before completion
NCT03768999 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 16 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Non-contrast magnetic resonance coronary angiography (MRCA) is the first listed.
NCT03768999 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03768999 about?
NCT03768999 is a clinical study titled "Comparison of Magnetic Resonance Coronary Angiography (MRCA) With Coronary Computed Tomography Angiography (CTA)". Magnetic resonance coronary angiography (MRCA) has its advantage in its ability to assess the coronary artery morphology without radiation or contrast media. The clinical application of MRCA is still challenging mainly because of technical limitations such as: its time-consuming image acquisition, i...
What is the current status of trial NCT03768999?
This trial is currently terminated. The enrollment target is 16 participants. The study started on 2019-09-03. Estimated completion is 2025-07-31.
What interventions are being tested in trial NCT03768999?
The interventions under investigation include: Non-contrast magnetic resonance coronary angiography (MRCA) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT03768999?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
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