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NCT03761030 · ClinicalTrials.gov registry record · Phase 4
L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults
A Phase 4 study, sponsored by New York State Psychiatric Institute.
- Terminated
- Registry status
- Phase 4
- Development phase
- 51
- Enrollment target
NCT03761030 is a Phase 4 study that was terminated before completion, run by New York State Psychiatric Institute. The registered enrollment target is 51 participants.
The verdict
NCT03761030, a Phase 4 study, was terminated before completion, sponsored by New York State Psychiatric Institute.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 51 participants
- Enrollment target
Study Summary
Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response. Our group and others have shown that decreased thinking speed is the central cause of functional problems in patients with LLD. Similarly, decreased walking speed is associated with depression and carries additional risk for falls, hospitalization, and death. Available evidence suggests that declining functionality in the brain's dopamine system contributes to age-related cognitive and motor slowing. The central hypothesis of this study is that by enhancing dopamine functioning in the brain and improving cognitive and motor slowing, administration of carbidopa/levodopa (L-DOPA) will improve depressive symptoms in older adults.
Interventions
- DRUG Placebo Oral Tablet
- DRUG L-DOPA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2019-01-09 |
| Est. Completion | 2021-09-08 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03761030
The ClinicalTrials.gov registry entry for NCT03761030 describes a study currently listed as terminated, categorized as Phase 4. The registered enrollment target is 51 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is New York State Psychiatric Institute, which has 364 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo Oral Tablet is the first listed.
NCT03761030 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03761030 about?
NCT03761030 is a clinical study titled "L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older Adults". Individuals with Late Life Depression (LLD) often have cognitive problems, particularly problems with memory, attention, and problem solving, all of which contribute to antidepressant non-response. Our group and others have shown that decreased thinking speed is the central cause of functional probl...
What is the current status of trial NCT03761030?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 51 participants. The study started on 2019-01-09. Estimated completion is 2021-09-08.
What interventions are being tested in trial NCT03761030?
The interventions under investigation include: Placebo Oral Tablet (DRUG), L-DOPA (DRUG).
Who is sponsoring clinical trial NCT03761030?
This trial is sponsored by New York State Psychiatric Institute, which has 364 total clinical trials registered on ClinicalTrials.gov.
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