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NCT03755362 · ClinicalTrials.gov registry record · NA
Dental Carotid Cognitive Study
A NA study, sponsored by University of Maryland, Baltimore.
- Terminated
- Registry status
- NA
- Development phase
- 26
- Enrollment target
NCT03755362: Clinical Trial NA study, sponsored by University of Maryland, Baltimore.
NCT03755362 is a NA study that was terminated before completion, run by University of Maryland, Baltimore. The registered enrollment target is 26 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03755362, a NA study, was terminated before completion, sponsored by University of Maryland, Baltimore.
- TERMINATED
- Registry status
- NA
- Development phase
- 26 participants
- Enrollment target
Study Summary
Periodontal Disease (PD) is present in 60+% of adults \>65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive impairment (MCI). Older MCI patients are prone to poor oral hygiene and dental health, which if untreated worsens inflammation-mediated brain and nervous system function, and accelerates progression to dementia. Asymptomatic carotid artery stenosis (ACAS) is often a silent disease detected in only \~10% of older adults, and may have a strong association with MCI. This study examines the effects of intensive therapy for periodontitis on cognition in high-risk older people with ACAS. Results could highlight PD as a readily modifiable risk factor for dementia.
Primary Outcome
The Montreal Cognitive Assessment (MoCA) is 30 item screening tool used to detect cognitive impairment. Score: 30 points (maximum), 0 points (minimum). Higher scores indicate better cognitive function. Differences in rate of change of MoCA score in those on intensive treatment for periodontitis and those receiving standard care.
Interventions
- PROCEDURE Standard Treatment
- PROCEDURE Intensive Treatment
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2019-04-08 |
| Est. Completion | 2021-02-25 |
| Phase | NA |
Why NCT03755362 stopped before completion
NCT03755362 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Standard Treatment is the first listed.
NCT03755362 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03755362 about?
NCT03755362 is a clinical study titled "Dental Carotid Cognitive Study". Periodontal Disease (PD) is present in 60+% of adults \>65 years and is associated with tobacco smoking, diabetes, and atherosclerosis that worsen inflammation, comorbidities common in older people with mild to moderate cognitive impairment (MCI). Older MCI patients are prone to poor oral hygiene an...
What is the current status of trial NCT03755362?
This trial is currently terminated. It is a NA study. The enrollment target is 26 participants. The study started on 2019-04-08. Estimated completion is 2021-02-25.
What interventions are being tested in trial NCT03755362?
The interventions under investigation include: Standard Treatment (PROCEDURE), Intensive Treatment (PROCEDURE).
Who is sponsoring clinical trial NCT03755362?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03755362's enrollment target sits among peer trials
26 1710th of 2000 higher than 289 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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