Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03733470 · ClinicalTrials.gov registry record · Phase 4
Hypoxic Pulmonary Vasoconstriction Pilot Study
A Phase 4 study, sponsored by Eric A. Hoffman.
- Completed
- Registry status
- Phase 4
- Development phase
- 22
- Enrollment target
NCT03733470: Completed Phase 4 study, sponsored by Eric A. Hoffman.
NCT03733470 is a Phase 4 study that has completed, run by Eric A. Hoffman. The registered enrollment target is 22 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03733470, a Phase 4 study, has completed, sponsored by Eric A. Hoffman.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 22 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.
Primary Outcome
Perfused blood volume will be measured by CT scan at two time points and compared at two points, pre and post the administration of sildenafil.
Interventions
- DRUG Sildenafil study group
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2011-06-29 |
| Est. Completion | 2014-01-13 |
| Phase | Phase 4 |
What the finished NCT03733470 record still lists
NCT03733470 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Sildenafil study group is the first listed.
NCT03733470 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03733470 about?
NCT03733470 is a clinical study titled "Hypoxic Pulmonary Vasoconstriction Pilot Study". The purpose of this study is to determine if the events leading to smoking-associated centrilobular and paraseptal emphysema are caused by a failure of the lungs' inherent mechanisms to block hypoxic pulmonary vasoconstriction (HPV) in areas of smoking-induced inflammation.
What is the current status of trial NCT03733470?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 22 participants. The study started on 2011-06-29. Estimated completion is 2014-01-13.
What interventions are being tested in trial NCT03733470?
The interventions under investigation include: Sildenafil study group (DRUG).
Who is sponsoring clinical trial NCT03733470?
This trial is sponsored by Eric A. Hoffman, which has 5 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03733470's enrollment target sits among peer trials
22 1731st of 2000 higher than 259 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02508038 · 22 participants · Phase 1
Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors
- NCT03099356 · 22 participants · Phase 2
Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid Cancer
- NCT03676647 · 22 participants
Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules
- NCT04569591 · 22 participants · NA
DDAVP for Pituitary Adenoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI