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NCT03727360 · ClinicalTrials.gov registry record · NA
Exercise for Brain Health in the Fight Against Alzheimer's Disease
A NA study, sponsored by University of Maryland, College Park.
- Completed
- Registry status
- NA
- Development phase
- 124
- Enrollment target
NCT03727360: Completed NA study, sponsored by University of Maryland, College Park.
NCT03727360 is a NA study that has completed, run by University of Maryland, College Park. The registered enrollment target is 124 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03727360, a NA study, has completed, sponsored by University of Maryland, College Park.
- COMPLETED
- Registry status
- NA
- Development phase
- 124 participants
- Enrollment target
Study Summary
The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-ε4) allele carriers are known to be at substantially greater risk for cognitive decline and Alzheimer's disease (AD). Cognitively intact APOE-ε4 allele carriers, and non-carriers, will be randomly assigned to 6-months of either supervised moderate intensity aerobic exercise training (ET) or supervised flexibility exercise control (FC). The ET and FC each contain a group based exercise component and are run in local retirement communities near College Park, MD, or on the University of Maryland College Park campus. The primary aims of the study are to compare pre-intervention to post-intervention changes in episodic memory performance and MRI biomarkers.
Primary Outcome
Rey Auditory Verbal Learning Test Sum of Trials 1-5. Fifteen words are presented verbally, and participant is asked to recall as many as possible after each trial. The total sum of the words correctly recalled across trials 1 to 5 is recorded.
Interventions
- OTHER Exercise Training
- OTHER Flexibility Control
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 124 participants |
| Start Date | 2018-10-08 |
| Est. Completion | 2024-04-30 |
| Phase | NA |
What the finished NCT03727360 record still lists
NCT03727360 is an interventional study that assigns participants to a tested intervention. The registered 124 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (91% lower).
The record links to 0 conditions, and to 2 interventions - of which Exercise Training is the first listed.
NCT03727360 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03727360 about?
NCT03727360 is a clinical study titled "Exercise for Brain Health in the Fight Against Alzheimer's Disease". The investigators aim to compare the effects of a 6-month moderate intensity exercise training (ET) intervention to a low intensity flexibility exercise control condition (FC) on brain function, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80)...
What is the current status of trial NCT03727360?
This trial is currently completed. It is a NA study. The enrollment target is 124 participants. The study started on 2018-10-08. Estimated completion is 2024-04-30.
What interventions are being tested in trial NCT03727360?
The interventions under investigation include: Exercise Training (OTHER), Flexibility Control (OTHER).
Who is sponsoring clinical trial NCT03727360?
This trial is sponsored by University of Maryland, College Park, which has 46 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03727360's enrollment target sits among peer trials
124 758th of 2000 higher than 1,239 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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