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NCT03724149 · ClinicalTrials.gov registry record · Phase 1
Transplanting Hepatitis C Lungs Into Negative Lung Recipients
A Phase 1 study, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
NCT03724149: Completed Phase 1 study, sponsored by University of Pennsylvania.
NCT03724149 is a Phase 1 study that has completed, run by University of Pennsylvania. The registered enrollment target is 10 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03724149, a Phase 1 study, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
Study Summary
This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with appropriate direct-acting antiviral (DAA) after transplantation.
Primary Outcome
The primary outcome measure is Sustained Virologic Response (SVR) rate at 12 weeks (number of subjects with SVR; negative HCV RNA after completing therapy) / (number of subjects treated post-lung transplantation). SVR will be based on the standard definition of SVR-12, defined as an undetectable HCV RNA in a subject's serum 12 weeks after completing treatment for HCV (12 weeks after the subject takes the last dose of Zepatier, Epclusa, or another appropriate antiviral treatment).
Interventions
- DRUG Epclusa
- DRUG Zepatier
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2018-12-12 |
| Est. Completion | 2022-12-31 |
| Phase | Phase 1 |
What the finished NCT03724149 record still lists
NCT03724149 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 2 interventions - of which Epclusa is the first listed.
NCT03724149 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03724149 about?
NCT03724149 is a clinical study titled "Transplanting Hepatitis C Lungs Into Negative Lung Recipients". This study is being conducted to determine safety and effectiveness of transplanting lungs from Hepatitis C-positive donors into Hepatitis C-negative patients on the lung transplant waitlist, who will then be treated with appropriate direct-acting antiviral (DAA) after transplantation.
What is the current status of trial NCT03724149?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2018-12-12. Estimated completion is 2022-12-31.
What interventions are being tested in trial NCT03724149?
The interventions under investigation include: Epclusa (DRUG), Zepatier (DRUG).
Who is sponsoring clinical trial NCT03724149?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03724149's enrollment target sits among peer trials
10 1913th of 2000 higher than 46 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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