Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03723668 · ClinicalTrials.gov registry record
Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France
A clinical trial, sponsored by Paris Translational Research Center for Organ Transplantation.
- Completed
- Registry status
- 94,017
- Enrollment target
NCT03723668 is a clinical trial that has completed, run by Paris Translational Research Center for Organ Transplantation. The registered enrollment target is 94,017 participants.
The verdict
NCT03723668 has completed, sponsored by Paris Translational Research Center for Organ Transplantation.
- COMPLETED
- Registry status
- 94,017 participants
- Enrollment target
Study Summary
Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years. The worldwide scarcity of donated kidneys and the decline in the number of living donor transplants have prompted a variety of efforts to expand the organ supply, such as accepting organs from donors who were older or had comorbidities or other injuries. Two major initiatives from the United Network for Organ Sharing (UNOS), the organization responsible for organ allocation in the US, failed to improve the kidney acceptance rate. First, UNOS introduced the Kidney Donor Risk Index (KDRI) for all kidney offers in 2012. The KDRI is a score that predicts survival of deceased donor kidneys based on 10 donor characteristics and was intended to simplify the process of judging organ quality for clinicians. Second, in 2014, UNOS changed the kidney allocation system so that lower-quality kidneys are offered over wider geographic areas. Despite the ongoing severe organ shortage and these allocation initiatives, the number of discarded kidneys rose from 2,127 (14.9%) in 2006 to 3,631 (20%) in 2016. In this context, the experience of transplant programs outside the US could offer novel approaches to making organ utilization more efficient through the examination of the disposition of organs that are usually discarded in the US. This project aims: 1. To evaluate the potential benefit of transplanting kidneys that would have been discarded otherwise in the US 2. Computer simulation models on real life data to estimate the number of kidney transplants that would have taken place using data from a nationwide cohort study in two countries (France, the US); 3. To evaluate the potential gains in allograft survival years that would result in the US from a less restrictive kidney acceptance practice such as the one from France.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 94,017 participants |
| Start Date | 2017-10-09 |
| Est. Completion | 2020-03-29 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03723668
The ClinicalTrials.gov registry entry for NCT03723668 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 94,017 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Paris Translational Research Center for Organ Transplantation, which has 7 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT03723668 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT03723668 about?
NCT03723668 is a clinical study titled "Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France". Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years. The worldwide scarcity of donated kidneys and the decline in the number of living donor transplants have...
What is the current status of trial NCT03723668?
This trial is currently completed. The enrollment target is 94,017 participants. The study started on 2017-10-09. Estimated completion is 2020-03-29.
Who is sponsoring clinical trial NCT03723668?
This trial is sponsored by Paris Translational Research Center for Organ Transplantation, which has 7 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.