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NCT03723668 · ClinicalTrials.gov registry record
Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France
A clinical trial, sponsored by Paris Translational Research Center for Organ Transplantation.
- Completed
- Registry status
- 94,017
- Enrollment target
NCT03723668: Completed study, sponsored by Paris Translational Research Center for Organ Transplantation.
NCT03723668 is a clinical trial that has completed, run by Paris Translational Research Center for Organ Transplantation. The registered enrollment target is 94,017 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03723668 has completed, sponsored by Paris Translational Research Center for Organ Transplantation.
- COMPLETED
- Registry status
- 94,017 participants
- Enrollment target
Study Summary
Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years. The worldwide scarcity of donated kidneys and the decline in the number of living donor transplants have prompted a variety of efforts to expand the organ supply, such as accepting organs from donors who were older or had comorbidities or other injuries. Two major initiatives from the United Network for Organ Sharing (UNOS), the organization responsible for organ allocation in the US, failed to improve the kidney acceptance rate. First, UNOS introduced the Kidney Donor Risk Index (KDRI) for all kidney offers in 2012. The KDRI is a score that predicts survival of deceased donor kidneys based on 10 donor characteristics and was intended to simplify the process of judging organ quality for clinicians. Second, in 2014, UNOS changed the kidney allocation system so that lower-quality kidneys are offered over wider geographic areas. Despite the ongoing severe organ shortage and these allocation initiatives, the number of discarded kidneys rose from 2,127 (14.9%) in 2006 to 3,631 (20%) in 2016. In this context, the experience of transplant programs outside the US could offer novel approaches to making organ utilization more efficient through the examination of the disposition of organs that are usually discarded in the US. This project aims: 1. To evaluate the potential benefit of transplanting kidneys that would have been discarded otherwise in the US 2. Computer simulation models on real life data to estimate the number of kidney transplants that would have taken place using data from a nationwide cohort study in two countries (France, the US); 3. To evaluate the potential gains in allograft survival years that would result in the US from a less restrictive kidney acceptance practice such as the one from France.
Primary Outcome
In some instances, the two kidneys might be procured from one donor but one or both kidneys may eventually be discarded and thus, not transplanted. This information was retrieved in both the OPTN data system and CRISTAL registry.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 94,017 participants |
| Start Date | 2017-10-09 |
| Est. Completion | 2020-03-29 |
What the finished NCT03723668 record still lists
NCT03723668 is an observational study that tracks outcomes without assigning an intervention. Its 94,017 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 0 interventions.
NCT03723668 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03723668 about?
NCT03723668 is a clinical study titled "Kidney Transplant Outcome and Organ Acceptance Practice Pattern: A Nationwide Analyses in the US and France". Despite the considerable advances in short-term outcomes, kidney transplant recipients continue to suffer from late allograft failure, and little improvement has been made over the past 15 years. The worldwide scarcity of donated kidneys and the decline in the number of living donor transplants have...
What is the current status of trial NCT03723668?
This trial is currently completed. The enrollment target is 94,017 participants. The study started on 2017-10-09. Estimated completion is 2020-03-29.
Who is sponsoring clinical trial NCT03723668?
This trial is sponsored by Paris Translational Research Center for Organ Transplantation, which has 7 total clinical trials registered on ClinicalTrials.gov.
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